TY - JOUR SN - 1663-4365 A1 - Leeuwia, A A1 - Smith, L A1 - Melbourne, A A1 - Hughes, A A1 - Richards, M A1 - Prins, N A1 - Sokolska, MJ A1 - Atkinson, D A1 - Tillin, T A1 - Jager, R A1 - Chaturvedi, N A1 - van der Flier, W A1 - Barkhof, F KW - cerebral perfusion KW - arterial spin labeling KW - cognition KW - neuropsychology KW - vascular risk factors KW - ethnicity N2 - Introduction: Lower cerebral blood flow (CBF) is associated with cardiovascular disease and vascular risk factors, and is increasingly acknowledged as an important contributor to cognitive decline and dementia. In this cross-sectional study, we examined the association between CBF and cognitive functioning in a community-based, multi-ethnic cohort. Methods: From the SABRE (Southall and Brent Revisited) study, we included 214 European, 151 South Asian and 87 African Caribbean participants (71 ± 5 years; 39%F). We used 3T pseudo-continuous arterial spin labeling to estimate whole-brain, hematocrit corrected CBF. We measured global cognition and three cognitive domains (memory, executive functioning/attention and language) with a neuropsychological test battery. Associations were investigated using linear regression analyses, adjusted for demographic variables, vascular risk factors and MRI measures. Results: Across groups, we found an association between higher CBF and better performance on executive functioning/attention (standardized ß [stß] = 0.11, p < 0.05). Stratification for ethnicity showed associations between higher CBF and better performance on memory and executive functioning/attention in the white European group (stß = 0.14; p < 0.05 and stß = 0.18; p < 0.01 respectively), associations were weaker in the South Asian and African Caribbean groups. Conclusions: In a multi-ethnic community-based cohort we showed modest associations between CBF and cognitive functioning. In particular, we found an association between higher CBF and better performance on executive functioning/attention and memory in the white European group. The observations are consistent with the proposed role of cerebral hemodynamics in cognitive decline AV - public TI - Cerebral blood flow and cognitive functioning in a community-based, multi-ethnic cohort: The SABRE study N1 - Copyright © 2018 Leeuwis, Smith, Melbourne, Hughes, Richards, Prins, Sokolska, Atkinson, Tillin, Jäger, Chaturvedi, Flier and Barkhof. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ID - discovery10056459 UR - http://doi.org/10.3389/fnagi.2018.00279 Y1 - 2018/09/18/ PB - Frontiers Media JF - Frontiers in Aging Neuroscience VL - 10 ER -