TY  - JOUR
VL  - 78
SP  - 3731
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 13
SN  - 1538-7445
UR  - http://doi.org/10.1158/0008-5472.CAN-17-3175
JF  - Cancer Research
A1  - Rossi, G
A1  - Redaelli, V
A1  - Contiero, P
A1  - Fabiano, S
A1  - Tagliabue, G
A1  - Perego, P
A1  - Benussi, L
A1  - Bruni, AC
A1  - Filippini, G
A1  - Farinotti, M
A1  - Giaccone, G
A1  - Buiatiotis, S
A1  - Manzoni, C
A1  - Ferrari, R
A1  - Tagliavini, F
TI  - Tau Mutations Serve as a Novel Risk Factor for Cancer
EP  - 3739
AV  - public
Y1  - 2018/07//
ID  - discovery10056116
N2  - In addition to its well-recognized role in neurodegeneration, tau participates in maintenance of genome stability and chromosome integrity. In particular, peripheral cells from patients affected by frontotemporal lobar degeneration carrying a mutation in tau gene (genetic tauopathies), as well as cells from animal models, show chromosome numerical and structural aberrations, chromatin anomalies, and a propensity toward abnormal recombination. As genome instability is tightly linked to cancer development, we hypothesized that mutated tau may be a susceptibility factor for cancer. Here we conducted a retrospective cohort study comparing cancer incidence in families affected by genetic tauopathies to control families. In addition, we carried out a bioinformatics analysis to highlight pathways associated with the tau protein interactome. We report that the risk of developing cancer is significantly higher in families affected by genetic tauopathies, and a high proportion of tau protein interactors are involved in cellular processes particularly relevant to cancer. These findings disclose a novel role of tau as a risk factor for cancer, providing new insights in the various pathologic roles of mutated tau.
PB  - AMER ASSOC CANCER RESEARCH
KW  - neurodegeneration; cancer; tau; MAPT; mutation; risk factor; epidemiology;
bioinformatics
ER  -