eprintid: 10056013
rev_number: 38
eprint_status: archive
userid: 608
dir: disk0/10/05/60/13
datestamp: 2018-09-17 14:45:16
lastmod: 2021-11-07 23:49:48
status_changed: 2018-09-17 14:45:16
type: article
metadata_visibility: show
creators_name: Antelmi, E
creators_name: Erro, R
creators_name: Rocchi, L
creators_name: Liguori, R
creators_name: Tinazzi, M
creators_name: Di Stasio, F
creators_name: Berardelli, A
creators_name: Rothwell, JC
creators_name: Bhatia, KP
title: Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: dystonia, neurophysiology, cortical inhibition, somatosensory temporal discrimination
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: Somatosensory temporal discrimination threshold is often prolonged in patients with dystonia. Previous evidence suggested that this might be caused by impaired somatosensory processing in the time domain. Here, we tested if other markers of reduced inhibition in the somatosensory system might also contribute to abnormal somatosensory temporal discrimination in dystonia. METHODS: Somatosensory temporal discrimination threshold was measured in 19 patients with isolated cervical dystonia and 19 age‐matched healthy controls. We evaluated temporal somatosensory inhibition using paired‐pulse somatosensory evoked potentials, spatial somatosensory inhibition by measuring the somatosensory evoked potentials interaction between simultaneous stimulation of the digital nerves in thumb and index finger, and Gamma‐aminobutyric acid‐ergic (GABAergic) sensory inhibition using the early and late components of high‐frequency oscillations in digital nerves somatosensory evoked potentials. RESULTS: When compared with healthy controls, dystonic patients had longer somatosensory temporal discrimination thresholds, reduced suppression of cortical and subcortical paired‐pulse somatosensory evoked potentials, less spatial inhibition of simultaneous somatosensory evoked potentials, and a smaller area of the early component of the high‐frequency oscillations. A logistic regression analysis found that paired pulse suppression of the N20 component at an interstimulus interval of 5 milliseconds and the late component of the high‐frequency oscillations were independently related to somatosensory temporal discrimination thresholds. “Dystonia group” was also a predictor of enhanced somatosensory temporal discrimination threshold, indicating a dystonia‐specific effect that independently influences this threshold. CONCLUSIONS: Increased somatosensory temporal discrimination threshold in dystonia is related to reduced activity of inhibitory circuits within the primary somatosensory cortex. © 2016 International Parkinson and Movement Disorder Society.
date: 2017-01
date_type: published
publisher: WILEY
official_url: https://doi.org/10.1002/mds.26804
full_text_type: other
language: eng
article_type_text: Journal Article
verified: verified_manual
elements_id: 1181584
doi: 10.1002/mds.26804
language_elements: English
lyricists_name: Bhatia, Kailash
lyricists_name: Rocchi, Lorenzo
lyricists_name: Rothwell, John
lyricists_id: KPBHA96
lyricists_id: LROCC06
lyricists_id: JCROT52
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: restricted
publication: Movement Disorders
volume: 32
number: 1
pagerange: 141-148
pages: 8
issn: 0885-3185
citation:        Antelmi, E;    Erro, R;    Rocchi, L;    Liguori, R;    Tinazzi, M;    Di Stasio, F;    Berardelli, A;         ... Bhatia, KP; + view all <#>        Antelmi, E;  Erro, R;  Rocchi, L;  Liguori, R;  Tinazzi, M;  Di Stasio, F;  Berardelli, A;  Rothwell, JC;  Bhatia, KP;   - view fewer <#>    (2017)    Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia.                   Movement Disorders , 32  (1)   pp. 141-148.    10.1002/mds.26804 <https://doi.org/10.1002/mds.26804>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10056013/1/Rothwell_Neurophysiological%20Correlates%20of%20Abnormal%20Somatosensory%20Temporal%20Discrimination%20in%20Dystonia_AAM.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/10056013/6/Rothwell_Neurophysiological%20Correlates%20of%20Abnormal%20Somatosensory%20Temporal%20Discrimination%20in%20Dystonia_Supp1_AAM.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/10056013/11/Rothwell_Neurophysiological%20Correlates%20of%20Abnormal%20Somatosensory%20Temporal%20Discrimination%20in%20Dystonia_Supp2_AAM.pdf