eprintid: 10056013 rev_number: 38 eprint_status: archive userid: 608 dir: disk0/10/05/60/13 datestamp: 2018-09-17 14:45:16 lastmod: 2021-11-07 23:49:48 status_changed: 2018-09-17 14:45:16 type: article metadata_visibility: show creators_name: Antelmi, E creators_name: Erro, R creators_name: Rocchi, L creators_name: Liguori, R creators_name: Tinazzi, M creators_name: Di Stasio, F creators_name: Berardelli, A creators_name: Rothwell, JC creators_name: Bhatia, KP title: Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 keywords: dystonia, neurophysiology, cortical inhibition, somatosensory temporal discrimination note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: BACKGROUND: Somatosensory temporal discrimination threshold is often prolonged in patients with dystonia. Previous evidence suggested that this might be caused by impaired somatosensory processing in the time domain. Here, we tested if other markers of reduced inhibition in the somatosensory system might also contribute to abnormal somatosensory temporal discrimination in dystonia. METHODS: Somatosensory temporal discrimination threshold was measured in 19 patients with isolated cervical dystonia and 19 age‐matched healthy controls. We evaluated temporal somatosensory inhibition using paired‐pulse somatosensory evoked potentials, spatial somatosensory inhibition by measuring the somatosensory evoked potentials interaction between simultaneous stimulation of the digital nerves in thumb and index finger, and Gamma‐aminobutyric acid‐ergic (GABAergic) sensory inhibition using the early and late components of high‐frequency oscillations in digital nerves somatosensory evoked potentials. RESULTS: When compared with healthy controls, dystonic patients had longer somatosensory temporal discrimination thresholds, reduced suppression of cortical and subcortical paired‐pulse somatosensory evoked potentials, less spatial inhibition of simultaneous somatosensory evoked potentials, and a smaller area of the early component of the high‐frequency oscillations. A logistic regression analysis found that paired pulse suppression of the N20 component at an interstimulus interval of 5 milliseconds and the late component of the high‐frequency oscillations were independently related to somatosensory temporal discrimination thresholds. “Dystonia group” was also a predictor of enhanced somatosensory temporal discrimination threshold, indicating a dystonia‐specific effect that independently influences this threshold. CONCLUSIONS: Increased somatosensory temporal discrimination threshold in dystonia is related to reduced activity of inhibitory circuits within the primary somatosensory cortex. © 2016 International Parkinson and Movement Disorder Society. date: 2017-01 date_type: published publisher: WILEY official_url: https://doi.org/10.1002/mds.26804 full_text_type: other language: eng article_type_text: Journal Article verified: verified_manual elements_id: 1181584 doi: 10.1002/mds.26804 language_elements: English lyricists_name: Bhatia, Kailash lyricists_name: Rocchi, Lorenzo lyricists_name: Rothwell, John lyricists_id: KPBHA96 lyricists_id: LROCC06 lyricists_id: JCROT52 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: restricted publication: Movement Disorders volume: 32 number: 1 pagerange: 141-148 pages: 8 issn: 0885-3185 citation: Antelmi, E; Erro, R; Rocchi, L; Liguori, R; Tinazzi, M; Di Stasio, F; Berardelli, A; ... Bhatia, KP; + view all <#> Antelmi, E; Erro, R; Rocchi, L; Liguori, R; Tinazzi, M; Di Stasio, F; Berardelli, A; Rothwell, JC; Bhatia, KP; - view fewer <#> (2017) Neurophysiological correlates of abnormal somatosensory temporal discrimination in dystonia. Movement Disorders , 32 (1) pp. 141-148. 10.1002/mds.26804 <https://doi.org/10.1002/mds.26804>. document_url: https://discovery.ucl.ac.uk/id/eprint/10056013/1/Rothwell_Neurophysiological%20Correlates%20of%20Abnormal%20Somatosensory%20Temporal%20Discrimination%20in%20Dystonia_AAM.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10056013/6/Rothwell_Neurophysiological%20Correlates%20of%20Abnormal%20Somatosensory%20Temporal%20Discrimination%20in%20Dystonia_Supp1_AAM.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10056013/11/Rothwell_Neurophysiological%20Correlates%20of%20Abnormal%20Somatosensory%20Temporal%20Discrimination%20in%20Dystonia_Supp2_AAM.pdf