eprintid: 10055853
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/05/58/53
datestamp: 2018-09-13 16:29:28
lastmod: 2021-11-10 23:20:31
status_changed: 2018-09-13 16:29:28
type: article
metadata_visibility: show
creators_name: Hewer, S
creators_name: Varley, S
creators_name: Boxer, AL
creators_name: Paul, E
creators_name: Williams, DR
creators_name: AL-108-231 Investigators, 
title: Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Minimal clinically important change (MCIC), progressive supranuclear palsy (PSP), progressive supranuclear palsy rating scale (PSPRS), Aged, Disease Progression, Female, Humans, Male, Middle Aged, Minimal Clinically Important Difference, Oligopeptides, Severity of Illness Index, Supranuclear Palsy, Progressive
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: Despite the widespread use of the Progressive Supranuclear Palsy Rating Scale (PSPRS), it is not known what change in this scale is meaningful for patients. METHODS: We analyzed data from a large clinical trial in PSP-Richardson's syndrome (AL-108-231) to calculate minimal clinically important worsening. This was defined as the difference in mean change of PSPRS in subjects rated "a little worse" and those rated "unchanged" on the Clinicians' Global Impression of Change Scale. A multivariate analysis using logistic regression assessed the relationship between clinical worsening, PSPRS, depression, and activities of daily living. RESULTS: The minimal clinically important worsening on the PSPRS was 5.7 points, corresponding to the mean decline over 6 months in the trial. Changes in activities of daily living and PSPRS were significantly associated with clinical worsening. CONCLUSIONS: Clinically meaningful change is measurable on the PSPRS over 6 months. © 2016 International Parkinson and Movement Disorder Society.
date: 2016-10-06
date_type: published
official_url: https://doi.org/10.1002/mds.26694
full_text_type: other
pmcid: PMC5215805
language: eng
article_type_text: Journal Article
verified: verified_manual
elements_id: 1574635
doi: 10.1002/mds.26694
lyricists_name: Lees, Andrew
lyricists_id: AJLEE60
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: restricted
publication: Movement Disorders
volume: 31
number: 10
pagerange: 1574-1577
event_location: United States
issn: 1531-8257
citation:        Hewer, S;    Varley, S;    Boxer, AL;    Paul, E;    Williams, DR;    AL-108-231 Investigators;      (2016)    Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale.                   Movement Disorders , 31  (10)   pp. 1574-1577.    10.1002/mds.26694 <https://doi.org/10.1002/mds.26694>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10055853/1/nihms839703.pdf