eprintid: 10055017
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/05/50/17
datestamp: 2018-08-30 15:34:40
lastmod: 2021-10-03 23:56:15
status_changed: 2018-08-30 15:34:40
type: article
metadata_visibility: show
creators_name: Orme, T
creators_name: Guerreiro, R
creators_name: Bras, J
title: The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Dementia with Lewy bodies, DLB, Genetics, GWAS, Next-generation sequencing, Genome-Wide Association, Alpha-Synuclein Gene, Familial Parkinsons-Disease, Beta-Glucocerebrosidase Activity, Alzheimers-Disease, Apolipoprotein-E, Body Disease, Frontotemporal Dementia, Locus Triplication, Gaucher-Disease
note: This article is distributed under the terms of the Creative
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abstract: PURPOSE OF REVIEW: 
Dementia with Lewy bodies (DLB) is a neurodegenerative disease that can be clinically and pathologically similar to Parkinson’s disease (PD) and Alzheimer’s disease (AD). Current understanding of DLB genetics is insufficient and has been limited by sample size and difficulty in diagnosis. The first genome-wide association study (GWAS) in DLB was performed in 2017; a time at which the post-GWAS era has been reached in many diseases.

RECENT FINDINGS: 
DLB shares risk loci with AD, in the APOE E4 allele, and with PD, in variation at GBA and SNCA. Interestingly, the GWAS suggested that DLB may also have genetic risk factors that are distinct from those in AD and PD.

SUMMARY: 
Although off to a slow start, recent studies have reinvigorated the field of DLB genetics and these results enable us to start to have a more complete understanding of the genetic architecture of this disease.
date: 2018-10
date_type: published
publisher: SPRINGER
official_url: http://doi.org/10.1007/s11910-018-0874-y
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1577786
doi: 10.1007/s11910-018-0874-y
language_elements: English
lyricists_name: Louro Guerreiro, Rita
lyricists_name: Orme, Tatiana
lyricists_name: Tomas Bras, Jose
lyricists_id: RJLOU51
lyricists_id: TJORM47
lyricists_id: JMTOM86
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Current Neurology and Neuroscience Reports
volume: 18
number: 10
article_number: 67
pages: 13
issn: 1534-6293
citation:        Orme, T;    Guerreiro, R;    Bras, J;      (2018)    The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions.                   Current Neurology and Neuroscience Reports , 18  (10)    , Article 67.  10.1007/s11910-018-0874-y <https://doi.org/10.1007/s11910-018-0874-y>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10055017/1/10.1007_s11910-018-0874-y.pdf