TY  - JOUR
VL  - 18
IS  - 10
N1  - This article is distributed under the terms of the Creative
Commons Attribution 4.0 International License (http://
creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
distribution, and reproduction in any medium, provided you give appropriate
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UR  - http://doi.org/10.1007/s11910-018-0874-y
SN  - 1534-6293
A1  - Orme, T
A1  - Guerreiro, R
A1  - Bras, J
JF  - Current Neurology and Neuroscience Reports
Y1  - 2018/10//
AV  - public
EP  - 13
TI  - The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions
PB  - SPRINGER
N2  - PURPOSE OF REVIEW: 
Dementia with Lewy bodies (DLB) is a neurodegenerative disease that can be clinically and pathologically similar to Parkinson?s disease (PD) and Alzheimer?s disease (AD). Current understanding of DLB genetics is insufficient and has been limited by sample size and difficulty in diagnosis. The first genome-wide association study (GWAS) in DLB was performed in 2017; a time at which the post-GWAS era has been reached in many diseases.

RECENT FINDINGS: 
DLB shares risk loci with AD, in the APOE E4 allele, and with PD, in variation at GBA and SNCA. Interestingly, the GWAS suggested that DLB may also have genetic risk factors that are distinct from those in AD and PD.

SUMMARY: 
Although off to a slow start, recent studies have reinvigorated the field of DLB genetics and these results enable us to start to have a more complete understanding of the genetic architecture of this disease.
ID  - discovery10055017
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Clinical Neurology
KW  -  Neurosciences
KW  -  Neurosciences & Neurology
KW  -  Dementia with Lewy bodies
KW  -  DLB
KW  -  Genetics
KW  -  GWAS
KW  -  Next-generation sequencing
KW  -  Genome-Wide Association
KW  -  Alpha-Synuclein Gene
KW  -  Familial Parkinsons-Disease
KW  -  Beta-Glucocerebrosidase Activity
KW  -  Alzheimers-Disease
KW  -  Apolipoprotein-E
KW  -  Body Disease
KW  -  Frontotemporal Dementia
KW  -  Locus Triplication
KW  -  Gaucher-Disease
ER  -