<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10054704> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/title> "Disclosure of amyloid positron emission tomography results to individuals without dementia: a systematic review"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Disclosure of amyloid positron emission tomography (PET) results to individuals without dementia\r\nhas become standard practice in secondary prevention trials and also increasingly occurs in clinical practice.\r\nHowever, this is controversial given the current lack of understanding of the predictive value of a PET result at the\r\nindividual level and absence of disease-modifying treatments. In this study, we systematically reviewed the literature\r\non the disclosure of amyloid PET in cognitively normal (CN) individuals and patients with mild cognitive\r\nimpairment (MCI) in both research and clinical settings.\r\nMETHODS: We performed a systematic literature search of four scientific databases. Two independent reviewers\r\nscreened the identified records and selected relevant articles. Included articles presented either empirical data or\r\ntheoretical data (i.e. arguments in favor or against amyloid status disclosure). Results from the theoretical data were\r\naggregated and presented per theme.\r\nRESULTS: Of the seventeen included studies, eleven reported empirical data and six provided theoretical arguments.\r\nThere was a large variation in the design of the empirical studies, which were almost exclusively in the context of\r\ncognitively normal trial participants, comprising only two prospective cohort studies quantitatively assessing the\r\npsychological impact of PET result disclosure which showed a low risk of psychological harm after disclosure. Four\r\nstudies showed that both professionals and cognitively normal individuals support amyloid PET result disclosure\r\nand underlined the need for clear disclosure protocols. From the articles presenting theoretical data, we identified\r\n51 ‘pro’ and ‘contra’ arguments. Theoretical arguments in favor or against disclosure were quite consistent across\r\npopulation groups and settings. Arguments against disclosure focused on the principle of non-maleficence,\r\nwhereas its psychological impact and predictive value is unknown. Important arguments in favor of amyloid\r\ndisclosure are the patients right to know (patient autonomy) and that it enables early future decision making.\r\nDISCUSSION: Before amyloid PET result disclosure in individuals without dementia in a research or clinical setting is\r\nready for widespread application, more research is needed about its psychological impact, and its predictive value\r\nat an individual level. Finally, communication materials and strategies to support disclosure of amyloid PET results\r\nshould be further developed and prospectively evaluated."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/date> "2018-07-28" . <https://discovery.ucl.ac.uk/id/document/721868> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/volume> "10" . <https://discovery.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> <http://xmlns.com/foaf/0.1/name> "BMC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> . <https://discovery.ucl.ac.uk/id/publication/ext-17589193> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-17589193> <http://xmlns.com/foaf/0.1/name> "Alzheimer's Research & Therapy"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-17589193> . <https://discovery.ucl.ac.uk/id/publication/ext-17589193> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:17589193> . <https://discovery.ucl.ac.uk/id/publication/ext-17589193> <http://purl.org/ontology/bibo/issn> "17589193" . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-46b00bdc221e0990b68ead51506b2c1f> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-46b00bdc221e0990b68ead51506b2c1f> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a89230046950bb61f53cfc85a33ffac8> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-a89230046950bb61f53cfc85a33ffac8> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-86ebd8923f20ad4b6184a2b2db41db4b> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-86ebd8923f20ad4b6184a2b2db41db4b> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a3e2c856be37e3271b1c10efa13180c0> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-a3e2c856be37e3271b1c10efa13180c0> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-45f9c9110e82e85d1f7e3273c15b85a3> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-45f9c9110e82e85d1f7e3273c15b85a3> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65430369ea3a98ee80262c6abebee52b> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-65430369ea3a98ee80262c6abebee52b> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bc602780754360f4ae42b18a5b95fbf0> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-bc602780754360f4ae42b18a5b95fbf0> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-22ab126f3d05ec2e9d55011a4eb1dadd> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> . <https://discovery.ucl.ac.uk/id/eprint/10054704#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-22ab126f3d05ec2e9d55011a4eb1dadd> . <https://discovery.ucl.ac.uk/id/person/ext-a89230046950bb61f53cfc85a33ffac8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a89230046950bb61f53cfc85a33ffac8> <http://xmlns.com/foaf/0.1/givenName> "MM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a89230046950bb61f53cfc85a33ffac8> <http://xmlns.com/foaf/0.1/familyName> "van Buchem"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a89230046950bb61f53cfc85a33ffac8> <http://xmlns.com/foaf/0.1/name> "MM van Buchem"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65430369ea3a98ee80262c6abebee52b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-65430369ea3a98ee80262c6abebee52b> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65430369ea3a98ee80262c6abebee52b> <http://xmlns.com/foaf/0.1/familyName> "Barkhof"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-65430369ea3a98ee80262c6abebee52b> <http://xmlns.com/foaf/0.1/name> "F Barkhof"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-46b00bdc221e0990b68ead51506b2c1f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-46b00bdc221e0990b68ead51506b2c1f> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-46b00bdc221e0990b68ead51506b2c1f> <http://xmlns.com/foaf/0.1/familyName> "de Wilde"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-46b00bdc221e0990b68ead51506b2c1f> <http://xmlns.com/foaf/0.1/name> "A de Wilde"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-86ebd8923f20ad4b6184a2b2db41db4b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-86ebd8923f20ad4b6184a2b2db41db4b> <http://xmlns.com/foaf/0.1/givenName> "RHJ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-86ebd8923f20ad4b6184a2b2db41db4b> <http://xmlns.com/foaf/0.1/familyName> "Otten"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-86ebd8923f20ad4b6184a2b2db41db4b> <http://xmlns.com/foaf/0.1/name> "RHJ Otten"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc602780754360f4ae42b18a5b95fbf0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bc602780754360f4ae42b18a5b95fbf0> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc602780754360f4ae42b18a5b95fbf0> <http://xmlns.com/foaf/0.1/familyName> "Scheltens"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc602780754360f4ae42b18a5b95fbf0> <http://xmlns.com/foaf/0.1/name> "P Scheltens"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-45f9c9110e82e85d1f7e3273c15b85a3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-45f9c9110e82e85d1f7e3273c15b85a3> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-45f9c9110e82e85d1f7e3273c15b85a3> <http://xmlns.com/foaf/0.1/familyName> "Stephens"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-45f9c9110e82e85d1f7e3273c15b85a3> <http://xmlns.com/foaf/0.1/name> "A Stephens"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22ab126f3d05ec2e9d55011a4eb1dadd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-22ab126f3d05ec2e9d55011a4eb1dadd> <http://xmlns.com/foaf/0.1/givenName> "WM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22ab126f3d05ec2e9d55011a4eb1dadd> <http://xmlns.com/foaf/0.1/familyName> "van der Flier"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-22ab126f3d05ec2e9d55011a4eb1dadd> <http://xmlns.com/foaf/0.1/name> "WM van der Flier"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a3e2c856be37e3271b1c10efa13180c0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a3e2c856be37e3271b1c10efa13180c0> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a3e2c856be37e3271b1c10efa13180c0> <http://xmlns.com/foaf/0.1/familyName> "Bouwman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a3e2c856be37e3271b1c10efa13180c0> <http://xmlns.com/foaf/0.1/name> "F Bouwman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10054704> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/721868> . 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