eprintid: 10054650 rev_number: 30 eprint_status: archive userid: 608 dir: disk0/10/05/46/50 datestamp: 2018-08-21 16:39:39 lastmod: 2021-12-16 01:38:12 status_changed: 2018-08-21 16:39:39 type: article metadata_visibility: show creators_name: McDowell, AR creators_name: Shelmerdine, SC creators_name: Carmichael, DW creators_name: Arthurs, OJ title: High resolution isotropic diffusion imaging in post-mortem neonates: a feasibility study ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F82 divisions: D13 divisions: G26 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: OBJECTIVE: To investigate the potential of advanced diffusion imaging in Post-Mortem MRI (PMMR) at 3T. Methods: We acquired PMMR brain and body imaging in 12 neonates, mean gestational age 33.4 weeks (range 29-37 weeks) at 3T and 1.5T. Head and body diffusion imaging at 1.5T using bipolar diffusion encoding and single-shot echo-planar imaging (EPI) for acquisition (TE 96ms; TR 2700ms; voxel size 1.8x1.8mm in-plane with slice thickness 5mm; b values of 500 and 1000 s/mm2 applied in three orthogonal directions; total acquisition time 2:12). A whole-body 3T diffusion imaging protocol using monopolar diffusion encoding and simultaneous multi-slice EPI acquisition with gradients applied in 12 uniformly distributed directions were obtained (TE 53.4ms; TR 5600ms; 1.8mm isotropic; multi-band factor 2; b-values of 250, 750, 1250 and 1750 s/mm2; acquisition time 2:09 for a single b-value,). Results: There was significant improvement in image quality in multiband, multi-slice diffusion PMMR protocol. On visual assessment of image quality, 1.5T DWI scored poorly (mean 2.4 SD ± 0.47), and all 3T b values individually scored significantly higher (p < 0.001) apart from b = 250 which was not significantly different. CONCLUSION: Recent advances in diffusion sequences and hardware utilising higher field strengths and gradient performance allows whole-body diffusion PMMR imaging at high resolution with improved image quality compared to the current clinical approach. Advances in knowledge: We have demonstrated feasibility of a multi-slice, multi-band quantitative diffusion imaging sequence in the perinatal post-mortem setting. This will allow more detailed and quantitative clinical PMMR investigations using diffusion MRI in the future. date: 2018 date_type: published official_url: https://doi.org/10.1259/bjr.20180319 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type: rapid_communication verified: verified_manual elements_id: 1568319 doi: 10.1259/bjr.20180319 lyricists_name: Arthurs, Owen lyricists_name: Carmichael, David lyricists_name: McDowell, Amy lyricists_name: Shelmerdine, Susan lyricists_id: OARTH57 lyricists_id: DWCAR66 lyricists_id: AMCDO89 lyricists_id: SCSHE38 actors_name: Sharp, Catherine actors_id: CLSHA04 actors_role: owner full_text_status: public publication: The British Journal of Radiology volume: 91 number: 1092 article_number: 20180319 event_location: England issn: 1748-880X citation: McDowell, AR; Shelmerdine, SC; Carmichael, DW; Arthurs, OJ; (2018) High resolution isotropic diffusion imaging in post-mortem neonates: a feasibility study. [Rapid communication]. The British Journal of Radiology , 91 (1092) , Article 20180319. 10.1259/bjr.20180319 <https://doi.org/10.1259/bjr.20180319>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10054650/1/bjr.20180319.pdf