@article{discovery10054650,
         journal = {The British Journal of Radiology},
            year = {2018},
          number = {1092},
           title = {High resolution isotropic diffusion imaging in post-mortem neonates: a feasibility study},
          volume = {91},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
          author = {McDowell, AR and Shelmerdine, SC and Carmichael, DW and Arthurs, OJ},
        abstract = {OBJECTIVE: To investigate the potential of advanced diffusion imaging in Post-Mortem MRI (PMMR) at 3T.� Methods: We acquired PMMR brain and body imaging in 12 neonates, mean gestational age 33.4 weeks (range 29-37 weeks) at 3T and 1.5T. Head and body diffusion imaging at 1.5T using bipolar diffusion encoding and single-shot echo-planar imaging (EPI) for acquisition (TE 96ms; TR 2700ms; voxel size 1.8x1.8mm in-plane with slice thickness 5mm; b values of 500 and 1000 s/mm2 applied in three orthogonal directions; total acquisition time 2:12). A whole-body 3T diffusion imaging protocol using monopolar diffusion encoding and simultaneous multi-slice EPI acquisition with gradients applied in 12 uniformly distributed directions were obtained (TE 53.4ms; TR 5600ms; 1.8mm isotropic; multi-band factor 2; b-values of 250, 750, 1250 and 1750 s/mm2; acquisition time 2:09 for a single b-value,).� Results: There�was significant improvement in image quality in multiband, multi-slice diffusion�PMMR protocol. On visual assessment of image quality, 1.5T DWI scored poorly (mean 2.4�SD {$\pm$} 0.47), and all 3T b values individually scored significantly higher (p�{\ensuremath{<}}�0.001) apart from�b�=�250 which was not significantly different. CONCLUSION: Recent advances in diffusion sequences and hardware utilising higher field strengths and�gradient performance allows whole-body diffusion PMMR imaging at high resolution with�improved image quality compared to the current clinical approach. Advances in knowledge: We have demonstrated feasibility of a multi-slice, multi-band quantitative diffusion imaging�sequence in the perinatal post-mortem setting. This will allow more detailed and�quantitative clinical PMMR investigations using diffusion MRI in the future.},
            issn = {1748-880X},
             url = {https://doi.org/10.1259/bjr.20180319}
}