eprintid: 10054566 rev_number: 30 eprint_status: archive userid: 608 dir: disk0/10/05/45/66 datestamp: 2018-08-21 14:56:17 lastmod: 2021-09-21 22:01:00 status_changed: 2018-08-21 14:56:17 type: article metadata_visibility: show creators_name: Stavrinides, V creators_name: Giganti, F creators_name: Emberton, M creators_name: Moore, CM title: MRI in active surveillance: a critical review ispublished: pub subjects: UCH divisions: UCL divisions: B02 divisions: C10 divisions: D16 divisions: G88 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: INTRODUCTION: Recent technological advancements and the introduction of modern anatomical and functional sequences have led to a growing role for multiparametric magnetic resonance imaging (mpMRI) in the detection, risk assessment and monitoring of early prostate cancer. This includes men who have been diagnosed with lower-risk prostate cancer and are looking at the option of active surveillance (AS). The purpose of this paper is to review the recent evidence supporting the use of mpMRI at different time points in AS, as well as to discuss some of its potential pitfalls. METHODS: A combination of electronic and manual searching methods were used to identify recent, important papers investigating the role of mpMRI in AS. RESULTS: The high negative predictive value of mpMRI can be exploited for the selection of AS candidates. In addition, mpMRI can be efficiently used to detect higher risk disease in patients already on surveillance. CONCLUSION: Although there is an ongoing debate regarding the precise nature of its optimal implementation, mpMRI is a promising risk stratification tool and should be considered for men on AS. date: 2019 date_type: published official_url: http://dx.doi.org/10.1038/s41391-018-0077-2 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1576942 doi: 10.1038/s41391-018-0077-2 pii: 10.1038/s41391-018-0077-2 lyricists_name: Emberton, Mark lyricists_name: Giganti, Francesco lyricists_name: Moore, Caroline lyricists_name: Stavrinides, Vasilis lyricists_id: MEMBE52 lyricists_id: FGIGA51 lyricists_id: CMMOO61 lyricists_id: VSTAV68 actors_name: Dewerpe, Marie actors_id: MDDEW97 actors_role: owner full_text_status: public publication: Prostate Cancer and Prostatic Diseases volume: 22 pagerange: 5-15 event_location: England issn: 1476-5608 citation: Stavrinides, V; Giganti, F; Emberton, M; Moore, CM; (2019) MRI in active surveillance: a critical review. Prostate Cancer and Prostatic Diseases , 22 pp. 5-15. 10.1038/s41391-018-0077-2 <https://doi.org/10.1038/s41391-018-0077-2>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10054566/3/Emberton_MRI%20in%20active%20surveillance%20-%20a%20critical%20review_PCAN-18-0113_MAIN_ARTICLE.pdf