eprintid: 10054536
rev_number: 23
eprint_status: archive
userid: 608
dir: disk0/10/05/45/36
datestamp: 2018-08-20 16:01:39
lastmod: 2020-02-12 22:14:17
status_changed: 2018-08-20 16:01:39
type: article
metadata_visibility: show
creators_name: Jacob, J
creators_name: Bartholmai, BJ
creators_name: Brun, AL
creators_name: Egashira, R
creators_name: Rajagopalan, S
creators_name: Karwoski, R
creators_name: Kouranos, V
creators_name: Kokosi, M
creators_name: Hansell, DM
creators_name: Wells, AU
title: Evaluation of visual and computer-based CT analysis for the identification of functional patterns of obstruction and restriction in hypersensitivity pneumonitis
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C10
divisions: D17
divisions: K71
keywords: Air trapping, hypersensitivity pneumonitis, pulmonary vessel volume, quantitative computer analysis, visual computed tomography analysis, Adult, Aged, Airway Obstruction, Airway Remodeling, Alveolitis, Extrinsic Allergic, Carbon Monoxide, Female, Humans, Image Interpretation, Computer-Assisted, Lung, Male, Middle Aged, Outcome Assessment (Health Care), Respiratory Function Tests, Tomography, X-Ray Computed
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND AND OBJECTIVE: To determine whether computer-based quantification (CALIPER software) is superior to visual computed tomography (CT) scoring in the identification of CT patterns indicative of restrictive and obstructive functional indices in hypersensitivity pneumonitis (HP). METHODS: A total of 135 consecutive HP patients had CT parenchymal patterns evaluated quantitatively by both visual scoring and CALIPER. Results were evaluated against: forced vital capacity (FVC), total lung capacity (TLC), diffusing capacity for carbon monoxide (DLCO ) and a composite physiological index (CPI) to identify which CT scoring method better correlated with functional indices. RESULTS: CALIPER-derived scores of total interstitial lung disease extent correlated more strongly than visual scores: FVC (CALIPER R = 0.73, visual R = 0.51); DLCO (CALIPER R = 0.61, visual R = 0.48); and CPI (CALIPER R = 0·70, visual R = 0·55). The CT variable that correlated most strongly with restrictive functional indices was CALIPER pulmonary vessel volume (PVV): FVC R = 0.75, DLCO R = 0.68 and CPI R = 0.76. Ground-glass opacity quantified by CALIPER alone demonstrated strong associations with restrictive functional indices: CALIPER FVC R = 0.65; DLCO R = 0.59; CPI R = 0.64; and visual = not significant. Decreased attenuation lung quantified by CALIPER was a better morphological measure of obstructive lung disease than equivalent visual scores as judged by relationships with TLC (CALIPER R = 0.63 and visual R = 0.12). All results were maintained on multivariate analysis. CONCLUSION: CALIPER improved on visual scoring in HP as judged by restrictive and obstructive functional correlations. Decreased attenuation regions of the lung quantified by CALIPER demonstrated better linkages to obstructive lung physiology than visually quantified CT scores. A novel CALIPER variable, the PVV, demonstrated the strongest linkages with restrictive functional indices and could represent a new automated index of disease severity in HP.
date: 2017-07-11
date_type: published
official_url: https://doi.org/10.1111/resp.13122
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1544147
doi: 10.1111/resp.13122
lyricists_name: Jacob, Joseph
lyricists_id: JJACO76
actors_name: Stacey, Thomas
actors_id: TSSTA20
actors_role: owner
full_text_status: public
publication: Respirology
volume: 22
number: 8
pagerange: 1585-1591
event_location: Australia
issn: 1440-1843
citation:        Jacob, J;    Bartholmai, BJ;    Brun, AL;    Egashira, R;    Rajagopalan, S;    Karwoski, R;    Kouranos, V;             ... Wells, AU; + view all <#>        Jacob, J;  Bartholmai, BJ;  Brun, AL;  Egashira, R;  Rajagopalan, S;  Karwoski, R;  Kouranos, V;  Kokosi, M;  Hansell, DM;  Wells, AU;   - view fewer <#>    (2017)    Evaluation of visual and computer-based CT analysis for the identification of functional patterns of obstruction and restriction in hypersensitivity pneumonitis.                   Respirology , 22  (8)   pp. 1585-1591.    10.1111/resp.13122 <https://doi.org/10.1111/resp.13122>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10054536/1/Jacob%20Evaluation%20of%20visual%20and%20computer-based%20CT%20analysis.pdf