eprintid: 10054061
rev_number: 44
eprint_status: archive
userid: 608
dir: disk0/10/05/40/61
datestamp: 2018-08-09 13:58:06
lastmod: 2021-09-25 23:05:26
status_changed: 2018-12-11 12:11:47
type: article
metadata_visibility: show
creators_name: Aristovich, KY
creators_name: Donega, M
creators_name: Blochet, C
creators_name: Avery, J
creators_name: Hannan, S
creators_name: Chew, D
creators_name: Holder, DS
title: Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
keywords: EIT, Electroseuticals, Imaging, Neural traffic, cuff electrode
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of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0). Any further
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abstract: Understanding the coding of neural activity in nerve fascicles is a high priority in computational neuroscience, electroceutical autonomic nerve stimulation and functional electrical stimulation for treatment of paraplegia. Unfortunately, it has been little studied as no technique has yet been available to permit imaging of neuronal depolarization within fascicles in peripheral nerve. We report a novel method for achieving this, using a flexible cylindrical multi-electrode cuff placed around nerve and the new medical imaging technique of fast neural Electrical Impedance Tomography (EIT). In rat sciatic nerve, it was possible to distinguish separate fascicles activated in response to direct electrical stimulation of the posterior tibial and common peroneal nerves. Reconstructed EIT images of fascicular activation corresponded with high spatial accuracy to the appropriate fascicles apparent in histology, as well as the inverse source analysis (ISA) of compound action potentials (CAP). With this method, a temporal resolution of 0.3 ms and spatial resolution of less than 100 µm was achieved. The method presented here is a potential solution for imaging activity within peripheral nerves with high spatial accuracy. It also provides a basis for imaging and selective neuromodulation to be incorporated in a single implantable non-penetrating peri-neural device.
date: 2018-10
date_type: published
official_url: http://doi.org/10.1088/1741-2552/aad78e
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1574223
doi: 10.1088/1741-2552/aad78e
lyricists_name: Aristovich, Kirill
lyricists_name: Avery, James
lyricists_name: Hannan, Sana
lyricists_name: Holder, David
lyricists_id: KARIS77
lyricists_id: JPAVE89
lyricists_id: SHANN04
lyricists_id: DSHOL61
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Journal of Neural Engineering
volume: 15
number: 5
article_number: 056025
event_location: England
issn: 1741-2552
citation:        Aristovich, KY;    Donega, M;    Blochet, C;    Avery, J;    Hannan, S;    Chew, D;    Holder, DS;      (2018)    Imaging fast neural traffic at fascicular level with electrical impedance tomography: proof of principle in rat sciatic nerve.                   Journal of Neural Engineering , 15  (5)    , Article 056025.  10.1088/1741-2552/aad78e <https://doi.org/10.1088/1741-2552%2Faad78e>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10054061/9/Aristovich_2018_J._Neural_Eng._15_0560251.pdf