eprintid: 10053958
rev_number: 21
eprint_status: archive
userid: 608
dir: disk0/10/05/39/58
datestamp: 2018-11-16 13:35:36
lastmod: 2021-10-14 22:46:49
status_changed: 2018-11-16 13:35:36
type: article
metadata_visibility: show
creators_name: Simitzi, C
creators_name: Ranella, A
creators_name: Stratakis, E
title: Controlling the morphology and outgrowth of nerve and neuroglial cells: The effect of surface topography
ispublished: pub
divisions: UCL
divisions: B04
divisions: C06
divisions: F62
divisions: ZZN
keywords: Topography, Nerve cells, Neuroglial cells, Micro-/nano-fabrication
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Unlike other tissue types, like epithelial tissue, which consist of cells with a much more homogeneous structure and function, the nervous tissue spans in a complex multilayer environment whose topographical features display a large spectrum of morphologies and size scales. Traditional cell cultures, which are based on two-dimensional cell-adhesive culture dishes or coverslips, are lacking topographical cues and mainly simulate the biochemical microenvironment of the cells. With the emergence of micro- and nano-fabrication techniques new types of cell culture platforms are developed, where the effect of various topographical cues on cellular morphology, proliferation and differentiation can be studied. Different approaches (regarding the material, fabrication technique, topographical characteristics, etc.) have been implemented. The present review paper aims at reviewing the existing body of literature on the use of artificial micro- and nano-topographical features to control neuronal and neuroglial cells’ morphology, outgrowth and neural network topology. The cell responses–from phenomenology to investigation of the underlying mechanisms- on the different topographies, including both deterministic and random ones, are summarize.
date: 2017-03-15
date_type: published
publisher: ELSEVIER SCI LTD
official_url: https://doi.org/10.1016/j.actbio.2017.01.023
oa_status: green
full_text_type: other
language: fin
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1521648
doi: 10.1016/j.actbio.2017.01.023
language_elements: English
lyricists_name: Simitzi, Charikleia
lyricists_id: CSIMI54
actors_name: Joyce, Sophia
actors_id: SJOYC12
actors_role: owner
full_text_status: public
publication: Acta Biomaterialia
volume: 51
pagerange: 21-52
pages: 32
issn: 1878-7568
citation:        Simitzi, C;    Ranella, A;    Stratakis, E;      (2017)    Controlling the morphology and outgrowth of nerve and neuroglial cells: The effect of surface topography.                   Acta Biomaterialia , 51    pp. 21-52.    10.1016/j.actbio.2017.01.023 <https://doi.org/10.1016/j.actbio.2017.01.023>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10053958/1/Controlling%20the%20morphology%20and%20outgrowth%20of%20nerve%20and%20neuroglial%20cells.pdf