eprintid: 10053767
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/05/37/67
datestamp: 2018-08-03 11:21:40
lastmod: 2021-09-24 22:10:31
status_changed: 2018-08-03 11:21:40
type: article
metadata_visibility: show
creators_name: Baake, V
creators_name: Coppen, EM
creators_name: van Duijn, E
creators_name: Dumas, EM
creators_name: van den Bogaard, SJA
creators_name: Scahill, RI
creators_name: Johnson, H
creators_name: Leavitt, B
creators_name: Durr, A
creators_name: Tabrizi, SJ
creators_name: Craufurd, D
creators_name: Roos, RAC
creators_name: Track-HD investigators, 
title: Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Apathy, Huntington's disease, Subcortical structures, Thalamus
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third party material in this article are included in the article’s Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
abstract: Background: Huntington's disease (HD) is characterized by motor and behavioral symptoms, and cognitive decline. HD gene carriers and their caregivers report the behavioral and cognitive symptoms as the most burdensome. Apathy is the most common behavioral symptom of HD and is related to clinical measures of disease progression, like functional capacity. However, it is unknown whether apathy is directly related to the neurodegenerative processes in HD. Objective: The aim is to investigate whether an association between atrophy of subcortical structures and apathy is present in HD, at baseline and after 2 years follow-up. Method: Volumes of 7 subcortical structures were measured using structural T1 MRI in 171 HD gene carriers of the TRACK-HD study and apathy was assessed with the Problem Behaviors Assessment-Short, at baseline and follow-up visit. At baseline, logistic regression was used to evaluate whether volumes of subcortical brain structures were associated with the presence of apathy. Linear regression was used to assess whether subcortical atrophy was associated with the degree of apathy at baseline and with an increase in severity of apathy over time. Results: At baseline, smaller volume of the thalamus showed a higher probability of the presence of apathy in HD gene carriers, but none of the subcortical structures was associated with the degree of apathy. Over time, no association between atrophy of any subcortical structures and change in degree of apathy was found. Conclusion: The presence of apathy is associated with atrophy of the thalamus in HD, suggesting that apathy has an underlying neural cause and might explain the high incidence of apathy in HD. However, no association was found between atrophy of these subcortical structures and increase in severity of apathy over a 2-year time period.
date: 2018-03-27
date_type: published
official_url: https://doi.org/10.1016/j.nicl.2018.03.033
oa_status: green
full_text_type: pub
pmcid: PMC6051315
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1571363
doi: 10.1016/j.nicl.2018.03.033
pii: S2213-1582(18)30103-7
lyricists_name: Cash, David
lyricists_name: Scahill, Rachael
lyricists_name: Tabrizi, Sarah
lyricists_id: DMCAS28
lyricists_id: RSCAH26
lyricists_id: SJTAB21
actors_name: Cuccu, Clara
actors_id: CCCUC40
actors_role: owner
full_text_status: public
publication: NeuroImage: Clinical
volume: 19
pagerange: 66-70
event_location: Netherlands
issn: 2213-1582
citation:        Baake, V;    Coppen, EM;    van Duijn, E;    Dumas, EM;    van den Bogaard, SJA;    Scahill, RI;    Johnson, H;                         ... Track-HD investigators; + view all <#>        Baake, V;  Coppen, EM;  van Duijn, E;  Dumas, EM;  van den Bogaard, SJA;  Scahill, RI;  Johnson, H;  Leavitt, B;  Durr, A;  Tabrizi, SJ;  Craufurd, D;  Roos, RAC;  Track-HD investigators;   - view fewer <#>    (2018)    Apathy and atrophy of subcortical brain structures in Huntington's disease: A two-year follow-up study.                   NeuroImage: Clinical , 19    pp. 66-70.    10.1016/j.nicl.2018.03.033 <https://doi.org/10.1016/j.nicl.2018.03.033>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10053767/1/Baake_Apathy.pdf