%I Springer
%L discovery10053645
%K Mixed effects model, Bivariate model, Trial, Diagnostic accuracy, Meta-analysis
%X In the present chapter, we discuss meta-analysis of clinical trials and compare them with meta-analysis of diagnostic accuracy studies. The former is based on the mixed effects model by DerSimonian and Laird (Control Clin Trials 7:177–188, 1986), and the latter is currently based on four main methods, with the most known bivariate model and the hierarchical summary receiver operator curve model. Each type of meta-analysis needs to be investigated for sources of heterogeneity. Specialist software exist to help each type of analysis.
%C Cham, Switzerland
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%A M Tsagris
%A K Fragkos
%E G Biondi-Zoccai
%T Meta-Analyses of Clinical Trials Versus Diagnostic Test Accuracy Studies
%B Diagnostic Meta-Analysis: A Useful Tool for Clinical Decision-Making
%P 31-40
%D 2018