%I Springer %L discovery10053645 %K Mixed effects model, Bivariate model, Trial, Diagnostic accuracy, Meta-analysis %X In the present chapter, we discuss meta-analysis of clinical trials and compare them with meta-analysis of diagnostic accuracy studies. The former is based on the mixed effects model by DerSimonian and Laird (Control Clin Trials 7:177–188, 1986), and the latter is currently based on four main methods, with the most known bivariate model and the hierarchical summary receiver operator curve model. Each type of meta-analysis needs to be investigated for sources of heterogeneity. Specialist software exist to help each type of analysis. %C Cham, Switzerland %O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. %A M Tsagris %A K Fragkos %E G Biondi-Zoccai %T Meta-Analyses of Clinical Trials Versus Diagnostic Test Accuracy Studies %B Diagnostic Meta-Analysis: A Useful Tool for Clinical Decision-Making %P 31-40 %D 2018