%0 Book Section %A Tsagris, M %A Fragkos, K %B Diagnostic Meta-Analysis: A Useful Tool for Clinical Decision-Making %C Cham, Switzerland %D 2018 %E Biondi-Zoccai, G %F discovery:10053645 %I Springer %K Mixed effects model, Bivariate model, Trial, Diagnostic accuracy, Meta-analysis %P 31-40 %T Meta-Analyses of Clinical Trials Versus Diagnostic Test Accuracy Studies %U https://discovery.ucl.ac.uk/id/eprint/10053645/ %X In the present chapter, we discuss meta-analysis of clinical trials and compare them with meta-analysis of diagnostic accuracy studies. The former is based on the mixed effects model by DerSimonian and Laird (Control Clin Trials 7:177–188, 1986), and the latter is currently based on four main methods, with the most known bivariate model and the hierarchical summary receiver operator curve model. Each type of meta-analysis needs to be investigated for sources of heterogeneity. Specialist software exist to help each type of analysis. %Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.