TY - CHAP AV - restricted SP - 43 A1 - Tsagris, M A1 - Fragkos, K KW - Evidence-based medicine KW - Meta-analysis KW - Meta-epidemiologic study KW - Overview of reviews KW - Umbrella reviews EP - 54 UR - https://doi.org/10.1007/978-3-319-25655-9_4 PB - Springer TI - Umbrella Reviews, Overviews of Reviews, and Meta-epidemiologic Studies: Similarities and Differences ID - discovery10053641 CY - Cham, Switzerland ED - Biondi-Zoccai, G Y1 - 2016/02/04/ N2 - This chapter describes umbrella reviews, overviews of reviews, and meta-epidemiologic studies focusing on their definitions, purposes, and classifications where appropriate and then elaborating on their similarities and differences. We may consider umbrella reviews as reviews integrating several types of study designs but typically randomized controlled trials and systematic reviews of such studies in a unifying fashion in order to address a content issue (e.g., whether or not a given drug is superior to another). Overviews of reviews are reviews of systematic reviews and meta-analyses which can focus on content or methodological issues. Finally, meta-epidemiologic studies focus on potentially different types of study designs but most typically on randomized trials and systematic reviews, usually across different content domains (e.g., topics or conditions), and mainly aim at addressing methodological issues. T2 - Umbrella Reviews: Evidence Synthesis with Overviews of Reviews and Meta-Epidemiologic Studies N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. ER -