eprintid: 10053562
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/05/35/62
datestamp: 2018-08-02 13:39:08
lastmod: 2021-10-09 22:54:09
status_changed: 2018-08-02 13:39:08
type: article
metadata_visibility: show
creators_name: Wareham, NE
creators_name: Da Cunha-Bang, C
creators_name: Borges, ÁH
creators_name: Ekenberg, C
creators_name: Gerstoft, J
creators_name: Gustafsson, F
creators_name: Hansen, D
creators_name: Heilmann, C
creators_name: Helleberg, M
creators_name: Hillingsø, J
creators_name: Krohn, PS
creators_name: Lodding, IP
creators_name: Lund, TK
creators_name: Lundgren, L
creators_name: Mocroft, A
creators_name: Perch, M
creators_name: Petersen, SL
creators_name: Petruskevicius, I
creators_name: Rasmussen, A
creators_name: Rossing, K
creators_name: Rostved, AA
creators_name: Sengeløv, H
creators_name: Sørensen, VR
creators_name: Sørensen, SS
creators_name: Lundgren, JD
title: Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results
ispublished: pub
divisions: UCL
divisions: B02
divisions: C09
divisions: D01
keywords: cancer, infection, methodology, transplantation death causes classification
note: Copyright © 2018 the Author(s).This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0), where it is
permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the
journal.
abstract: Correct classification of death causes is an important component of transplant trials.We aimed to develop and validate a system to classify causes of death in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients.Case record forms (CRF) of fatal cases were completed, including investigator-designated cause of death. Deaths occurring in 2010 to 2013 were used for derivation; and were validated by deaths occurring in 2013 to 2015. Underlying cause of death (referred to as recorded underlying cause) was determined through a central adjudication process involving 2 external reviewers, and subsequently compared with the Danish National Death Cause Registry.Three hundred eighty-eight recipients died 2010 to 2015 (196 [51%] SOT and 192 [49%] HSCT). The main recorded underlying causes of death among SOT and HSCT were classified as cancer (20%, 48%), graft rejection/failure/graft-versus-host-disease (35%, 28%), and infections (20%, 11%). Kappa between the investigator-designated and the recorded underlying cause of death was 0.74 (95% CI 0.69-0.80) in derivation and comparable in the validation cohort. Death causes were concordant with the Danish National Death Cause Registry in 37.2% (95% CI 31.5-42.9) and 38.4% (95% CI 28.8-48.0) in the derivation and validation cohorts, respectively.We developed and validated a method to systematically and reliably classify the underlying cause of death among transplant recipients. There was a high degree of discordance between this classification and that in the Danish National Death Cause Registry.
date: 2018-07
date_type: published
official_url: http://dx.doi.org/10.1097/MD.0000000000011564
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1571337
doi: 10.1097/MD.0000000000011564
pii: 00005792-201807200-00064
lyricists_name: Mocroft, Amanda
lyricists_id: AJMOC35
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Medicine
volume: 97
number: 29
article_number: e11564
event_location: United States
issn: 1536-5964
citation:        Wareham, NE;    Da Cunha-Bang, C;    Borges, ÁH;    Ekenberg, C;    Gerstoft, J;    Gustafsson, F;    Hansen, D;                                                                         ... Lundgren, JD; + view all <#>        Wareham, NE;  Da Cunha-Bang, C;  Borges, ÁH;  Ekenberg, C;  Gerstoft, J;  Gustafsson, F;  Hansen, D;  Heilmann, C;  Helleberg, M;  Hillingsø, J;  Krohn, PS;  Lodding, IP;  Lund, TK;  Lundgren, L;  Mocroft, A;  Perch, M;  Petersen, SL;  Petruskevicius, I;  Rasmussen, A;  Rossing, K;  Rostved, AA;  Sengeløv, H;  Sørensen, VR;  Sørensen, SS;  Lundgren, JD;   - view fewer <#>    (2018)    Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results.                   Medicine , 97  (29)    , Article e11564.  10.1097/MD.0000000000011564 <https://doi.org/10.1097/MD.0000000000011564>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10053562/1/Classification_of_death_causes_after.64.pdf