eprintid: 10053562 rev_number: 18 eprint_status: archive userid: 608 dir: disk0/10/05/35/62 datestamp: 2018-08-02 13:39:08 lastmod: 2021-10-09 22:54:09 status_changed: 2018-08-02 13:39:08 type: article metadata_visibility: show creators_name: Wareham, NE creators_name: Da Cunha-Bang, C creators_name: Borges, ÁH creators_name: Ekenberg, C creators_name: Gerstoft, J creators_name: Gustafsson, F creators_name: Hansen, D creators_name: Heilmann, C creators_name: Helleberg, M creators_name: Hillingsø, J creators_name: Krohn, PS creators_name: Lodding, IP creators_name: Lund, TK creators_name: Lundgren, L creators_name: Mocroft, A creators_name: Perch, M creators_name: Petersen, SL creators_name: Petruskevicius, I creators_name: Rasmussen, A creators_name: Rossing, K creators_name: Rostved, AA creators_name: Sengeløv, H creators_name: Sørensen, VR creators_name: Sørensen, SS creators_name: Lundgren, JD title: Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results ispublished: pub divisions: UCL divisions: B02 divisions: C09 divisions: D01 keywords: cancer, infection, methodology, transplantation death causes classification note: Copyright © 2018 the Author(s).This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. abstract: Correct classification of death causes is an important component of transplant trials.We aimed to develop and validate a system to classify causes of death in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients.Case record forms (CRF) of fatal cases were completed, including investigator-designated cause of death. Deaths occurring in 2010 to 2013 were used for derivation; and were validated by deaths occurring in 2013 to 2015. Underlying cause of death (referred to as recorded underlying cause) was determined through a central adjudication process involving 2 external reviewers, and subsequently compared with the Danish National Death Cause Registry.Three hundred eighty-eight recipients died 2010 to 2015 (196 [51%] SOT and 192 [49%] HSCT). The main recorded underlying causes of death among SOT and HSCT were classified as cancer (20%, 48%), graft rejection/failure/graft-versus-host-disease (35%, 28%), and infections (20%, 11%). Kappa between the investigator-designated and the recorded underlying cause of death was 0.74 (95% CI 0.69-0.80) in derivation and comparable in the validation cohort. Death causes were concordant with the Danish National Death Cause Registry in 37.2% (95% CI 31.5-42.9) and 38.4% (95% CI 28.8-48.0) in the derivation and validation cohorts, respectively.We developed and validated a method to systematically and reliably classify the underlying cause of death among transplant recipients. There was a high degree of discordance between this classification and that in the Danish National Death Cause Registry. date: 2018-07 date_type: published official_url: http://dx.doi.org/10.1097/MD.0000000000011564 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1571337 doi: 10.1097/MD.0000000000011564 pii: 00005792-201807200-00064 lyricists_name: Mocroft, Amanda lyricists_id: AJMOC35 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: Medicine volume: 97 number: 29 article_number: e11564 event_location: United States issn: 1536-5964 citation: Wareham, NE; Da Cunha-Bang, C; Borges, ÁH; Ekenberg, C; Gerstoft, J; Gustafsson, F; Hansen, D; ... Lundgren, JD; + view all <#> Wareham, NE; Da Cunha-Bang, C; Borges, ÁH; Ekenberg, C; Gerstoft, J; Gustafsson, F; Hansen, D; Heilmann, C; Helleberg, M; Hillingsø, J; Krohn, PS; Lodding, IP; Lund, TK; Lundgren, L; Mocroft, A; Perch, M; Petersen, SL; Petruskevicius, I; Rasmussen, A; Rossing, K; Rostved, AA; Sengeløv, H; Sørensen, VR; Sørensen, SS; Lundgren, JD; - view fewer <#> (2018) Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results. Medicine , 97 (29) , Article e11564. 10.1097/MD.0000000000011564 <https://doi.org/10.1097/MD.0000000000011564>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10053562/1/Classification_of_death_causes_after.64.pdf