TY  - JOUR
AV  - public
Y1  - 2016/06//
EP  - 255
TI  - Combined immunohistochemical and retrograde tracing reveals little evidence of innervation of the rat dentate gyrus by midbrain dopamine neurons
KW  - noradrenaline
KW  -  hippocampus
KW  -  connectivity
KW  -  DAT
KW  -  neurogenesis
N2  - Although the functional neuroanatomy of the midbrain dopamine (mDA) system has been well characterized, the literature regarding its capacity to innervate the hippocampal formation has been inconsistent. The lack of expression of definitive markers for dopaminergic fibers, such as the dopamine transporter, in the hippocampus has complicated studies in this area. Here we have used immunohistochemical techniques to characterize the tyrosine hydroxylase expressing fiber network in the rat hippocampus, combined with retrograde tracing from the dentate gyrus to assess the capacity for afferent innervation by mDA neurons. The results indicate that virtually all tyrosine hydroxylase fibers throughout the hippocampus are of a noradrenergic phenotype, while the overlying cortex contains both dopaminergic and noradrenergic fiber networks. Furthermore, retrograde tracing from the dentate gyrus robustly labels tyrosine hydroxylase-immunoreactive noradrenergic neurons in the locus coeruleus but not mDA neurons.
ID  - discovery10053413
IS  - 3
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
VL  - 11
SP  - 246
A1  - Ermine, CM
A1  - Wright, JL
A1  - Parish, CL
A1  - Stanic, D
A1  - Thompson, LH
JF  - Frontiers in Biology
UR  - http://dx.doi.org/10.1007/s11515-016-1404-4
SN  - 1674-7992
ER  -