eprintid: 10053327 rev_number: 43 eprint_status: archive userid: 608 dir: disk0/10/05/33/27 datestamp: 2018-07-26 12:15:21 lastmod: 2021-09-17 22:22:30 status_changed: 2019-01-30 15:58:11 type: article metadata_visibility: show creators_name: Sellami, L creators_name: Bocchetta, M creators_name: Masellis, M creators_name: Cash, DM creators_name: Dick, KM creators_name: van Swieten, J creators_name: Borroni, B creators_name: Galimberti, D creators_name: Tartaglia, MC creators_name: Rowe, JB creators_name: Graff, C creators_name: Tagliavini, F creators_name: Frisoni, G creators_name: Finger, E creators_name: de Mendonça, A creators_name: Sorbi, S creators_name: Warren, JD creators_name: Rohrer, JD creators_name: Laforcem, R title: Distinct Neuroanatomical Correlates of Neuropsychiatric Symptoms in the Three Main Forms of Genetic Frontotemporal Dementia in the GENFI Cohort ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: Frontotemporal dementia, genetics, magnetic resonance imaging, neuropsychiatry note: This version is the version of the record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Background: The overlap between frontotemporal dementia (FTD) and primary psychiatric disorders has been brought to light by reports of prominent neuropsychiatric symptoms (NPS) in FTD-related genetic mutations, particularly among C9orf72 and GRN carriers. It has been recently demonstrated that early neuroanatomical changes in genetic FTD may be different across the major disease-causing mutations. // Objective: We aimed to identify whether NPS could be driven by distinct structural correlates. // Methods: One hundred and sixty-seven mutation carriers (75 GRN, 60 C9orf72, and 32 MAPT) were included from the Genetic FTD Initiative (GENFI) study, a large international cohort of genetic FTD. Neuropsychiatric symptoms including delusions, hallucinations (visual, auditory, and tactile), depression, and anxiety were investigated using a structured interview. Voxel-based morphometry was performed to identify neuroanatomical correlates of NPS. // Results: Psychotic symptoms correlated mainly with grey matter (GM) atrophy in the anterior insula, left thalamus, cerebellum, and cortical regions including frontal, parietal, and occipital lobes in GRN mutations carriers. GM atrophy in posterior structures of the default-mode network was associated with anxiety in the GRN group. Delusions in C9orf72 expansion carriers were mainly associated with left frontal cortical atrophy. Cerebellar atrophy was found to be correlated only with anxiety in C9orf72 carriers. NPS in the MAPT group were mainly associated with volume loss in the temporal lobe. // Conclusion: Neuroanatomical correlates of NPS appear to be distinct across the main forms of genetic FTD. Overall, our findings support overlapping brain structural changes between FTD and primary psychiatric disorders. date: 2018-08-07 date_type: published official_url: http://dx.doi.org/10.3233/JAD-180053 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1571193 doi: 10.3233/JAD-180053 lyricists_name: Bocchetta, Martina lyricists_name: Cash, David lyricists_name: Fox, Nicholas lyricists_name: Moore, Katrina lyricists_name: Rohrer, Jonathan lyricists_name: Warren, Jason lyricists_id: MBOCC01 lyricists_id: DMCAS28 lyricists_id: NCIFO25 lyricists_id: KDICK46 lyricists_id: JDROH34 lyricists_id: JDWAR75 actors_name: Bocchetta, Martina actors_id: MBOCC01 actors_role: owner full_text_status: public publication: Journal of Alzheimer's Disease volume: 65 number: 1 pagerange: 147-163 issn: 1387-2877 citation: Sellami, L; Bocchetta, M; Masellis, M; Cash, DM; Dick, KM; van Swieten, J; Borroni, B; ... Laforcem, R; + view all <#> Sellami, L; Bocchetta, M; Masellis, M; Cash, DM; Dick, KM; van Swieten, J; Borroni, B; Galimberti, D; Tartaglia, MC; Rowe, JB; Graff, C; Tagliavini, F; Frisoni, G; Finger, E; de Mendonça, A; Sorbi, S; Warren, JD; Rohrer, JD; Laforcem, R; - view fewer <#> (2018) Distinct Neuroanatomical Correlates of Neuropsychiatric Symptoms in the Three Main Forms of Genetic Frontotemporal Dementia in the GENFI Cohort. Journal of Alzheimer's Disease , 65 (1) pp. 147-163. 10.3233/JAD-180053 <https://doi.org/10.3233/JAD-180053>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10053327/1/Sellami_jad_2018_65-1_jad-65-1-jad180053_jad-65-jad180053.pdf