eprintid: 10053261
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/05/32/61
datestamp: 2018-07-30 16:36:21
lastmod: 2020-02-12 22:04:31
status_changed: 2018-07-30 16:36:21
type: article
metadata_visibility: show
creators_name: Redahan, L
creators_name: Davenport, A
title: Peritoneal dialysate effluent and serum CA125 concentrations in stable peritoneal dialysis patients
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C10
divisions: D17
keywords: Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, Cancer Antigen 125, Peritoneal Dialysis, Glucose, Icodextrin, Residual Renal Function, Dwell Time, Extracellular Volume Expansion, Cancer Antigen-125, Multifrequency Bioimpedance, Transport, CA-125, CAPD, Hemodialysis, Sclerosis, Markers, Cells
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: INTRODUCTION: 
CA125 in peritoneal dialysis (PD) effluent dialysate has been used as a surrogate biomarker for the health of the peritoneum in PD patients. However CA125 is synthesised by epithelial cells and as such is not specific for the peritoneum, and most studies have only measured peritoneal CA125, without serum CA125 values. As such we wished to determine the factors which influenced PD effluent CA125 in a large contemporaneous cohort.


METHODS: 
We measured dialysate effluent CA125 in PD patients attending for routine assessment of peritoneal membrane function with a peritoneal equilibration test (PET), with corresponding serum CA125.

RESULTS: 
Serum and dialysate CA125 were measured in 205 PD patients; 59.0 ± 16.8 years, median PD treatment 3 (2–20) months, 59 % male, 42.4 % diabetic, with 31.2 % treated by continuous ambulatory peritoneal dialysis, 22 % by automated overnight peritoneal dialysis cycler (APD) and 46.8 % by APD with a day time exchange. The median serum CA125 was 21 (13–38) U/ml, with an effluent 4 h PD PET effluent of 20 (11.5–36.5) U/ml. PET PD effluent dialysate was associated with PET dialysate total protein (β 12.9, p < 0.001), serum CA125 (β 0.109, p = 0.002), residual renal function (β 0.53, p = 0.018) and age (β 0.145, p = 0.042) and negatively with the number of PD cycles/day (β −2.19, p = 0.001). There was no association with prior peritonitis episodes.

CONCLUSION: 
PD effluent CA125 concentrations were associated with peritoneal protein losses and increased by the usage of higher glucose dialysates to compensate for loss of residual renal function.
date: 2016-06
date_type: published
publisher: WICHTIG PUBLISHING
official_url: http://dx.doi.org/10.1007/s40620-015-0250-9
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1089338
doi: 10.1007/s40620-015-0250-9
language_elements: English
lyricists_name: Davenport, Andrew
lyricists_id: ADAVE78
actors_name: Davenport, Andrew
actors_name: Henderson, Kathryn
actors_id: ADAVE78
actors_id: KJHEN38
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Journal of Nephrology
volume: 29
number: 3
pagerange: 427-434
pages: 8
issn: 1724-6059
citation:        Redahan, L;    Davenport, A;      (2016)    Peritoneal dialysate effluent and serum CA125 concentrations in stable peritoneal dialysis patients.                   Journal of Nephrology , 29  (3)   pp. 427-434.    10.1007/s40620-015-0250-9 <https://doi.org/10.1007/s40620-015-0250-9>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10053261/3/Davenport_20JunePDILynnPDandSerumCA125paper.pdf