eprintid: 10053213
rev_number: 23
eprint_status: archive
userid: 608
dir: disk0/10/05/32/13
datestamp: 2018-07-27 16:53:35
lastmod: 2021-09-20 22:26:27
status_changed: 2018-07-27 16:53:35
type: article
metadata_visibility: show
creators_name: Burgess, K
creators_name: Li, H
creators_name: Abo-zeid, Y
creators_name: Fatimah, and
creators_name: Williams, GR
title: The Effect of Molecular Properties on Active Ingredient Release from Electrospun Eudragit Fibers
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: electrospinning; Eudragit; nanofibers; drug release
note: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
abstract: The formation of nanoscale fibers from pH-sensitive polymers is a route which has been widely explored for targeted drug delivery. In particular, the Eudragit L100 and S100 families of polymers have received significant attention for this purpose. However, while in some cases it is shown that making drug-loaded Eudragit polymers effectively prevents drug release in low-pH media where the polymer is insoluble, this is not always the case, and other studies have reported significant amounts of drug release at acidic pHs. In this study, we sought to gain insight into the factors influencing the release of active ingredients from Eudragit S100 (ES100) fibers. A family of materials was prepared loaded with the model active ingredients (AIs) benzoic acid, 1-naphthoic acid, 1-naphthylamine, and 9-anthracene carboxylic acid. Analogous systems were prepared with an AI-loaded core and an ES100 sheath. The resultant fibers were smooth and cylindrical in the majority of cases, and X-ray diffraction and differential scanning calorimetry showed them to comprise amorphous solid dispersions. When AI release from the monolithic fibers was probed, it was found that there was significant release at pH 1 in all cases except with 9-anthracene carboxylic acid. Analysis of the results indicated that both the molecular weight of the AI and its acidity/basicity are important in controlling release, with lower molecular weight AIs and basic species released more quickly. The same release trends are seen with the core/shell fibers, but AI release at pH 1 is attenuated. The most significant change between the monolithic and core/shell systems was observed in the case of 1-naphthylamine. Mathematical equations were devised to connect molecular properties and AI release under acidic conditions.
date: 2018-07-24
date_type: published
publisher: MDPI AG
official_url: http://doi.org/10.3390/pharmaceutics10030103
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1571085
doi: 10.3390/pharmaceutics10030103
lyricists_name: Abozeid, Yasmin
lyricists_name: Fatimah, Fatimah
lyricists_name: Li, Heyu
lyricists_name: Williams, Gareth
lyricists_id: YABOZ97
lyricists_id: FATIM29
lyricists_id: HLIBX67
lyricists_id: GWILL02
actors_name: Williams, Gareth
actors_id: GWILL02
actors_role: owner
full_text_status: public
publication: Pharmaceutics
volume: 10
number: 3
article_number: 103
issn: 1999-4923
citation:        Burgess, K;    Li, H;    Abo-zeid, Y;    Fatimah, and;    Williams, GR;      (2018)    The Effect of Molecular Properties on Active Ingredient Release from Electrospun Eudragit Fibers.                   Pharmaceutics , 10  (3)    , Article 103.  10.3390/pharmaceutics10030103 <https://doi.org/10.3390/pharmaceutics10030103>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10053213/1/GRW%20Pharmaceutics%202018.pdf