eprintid: 10053030 rev_number: 22 eprint_status: archive userid: 608 dir: disk0/10/05/30/30 datestamp: 2018-07-25 13:08:23 lastmod: 2021-09-17 22:13:13 status_changed: 2018-07-25 13:08:23 type: article metadata_visibility: show creators_name: Ni, G creators_name: Gratten, J creators_name: Wray, NR creators_name: Lee, SH creators_name: Ripke, S creators_name: Neale, BM creators_name: Corvin, A creators_name: Walters, JTR creators_name: Farh, KH creators_name: Holmans, PA creators_name: Lee, P creators_name: Bulik-Sullivan, B creators_name: Collier, DA creators_name: Huang, H creators_name: Pers, TH creators_name: Agartz, I creators_name: Agerbo, E creators_name: Albus, M creators_name: Alexander, M creators_name: Amin, F creators_name: Bacanu, SA creators_name: Begemann, M creators_name: Belliveau, RA creators_name: Bene, J creators_name: Bergen, SE creators_name: Bevilacqua, E creators_name: Bigdeli, TB creators_name: Black, DW creators_name: Bruggeman, R creators_name: Buccola, NG creators_name: Buckner, RL creators_name: Byerley, W creators_name: Cahn, W creators_name: Cai, G creators_name: Campion, D creators_name: Cantor, RM creators_name: Carr, VJ creators_name: Carrera, N creators_name: Catts, SV creators_name: Chambert, KD creators_name: Chan, RCK creators_name: Chen, RYL creators_name: Chen, EYH creators_name: Cheng, W creators_name: Cheung, EFC creators_name: Chong, SA creators_name: Cloninger, CR creators_name: Cohen, D creators_name: Cohen, N creators_name: Cormican, P creators_name: Craddock, N creators_name: Crowley, JJ creators_name: Curtis, D creators_name: Davidson, M creators_name: Davis, KL creators_name: Degenhardt, F creators_name: Del Favero, J creators_name: Demontis, D creators_name: Dikeos, D creators_name: Dinan, T creators_name: Djurovic, S creators_name: Donohoe, G creators_name: Drapeau, E creators_name: Psychiatric Genomics Consortium, Schizophrenia Working Group, . title: Age at first birth in women is genetically associated with increased risk of schizophrenia ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: C08 divisions: D09 divisions: F99 note: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. abstract: Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health. date: 2018 date_type: published official_url: https://doi.org/10.1038/s41598-018-28160-z oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1568318 doi: 10.1038/s41598-018-28160-z lyricists_name: Bramon, Elvira lyricists_name: Curtis, David lyricists_name: McQuillin, Andrew lyricists_id: EBRAM47 lyricists_id: DCURT26 lyricists_id: AMCQU28 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: Scientific Reports volume: 8 article_number: 10168 issn: 2045-2322 citation: Ni, G; Gratten, J; Wray, NR; Lee, SH; Ripke, S; Neale, BM; Corvin, A; ... Psychiatric Genomics Consortium, Schizophrenia Working Group, .; + view all <#> Ni, G; Gratten, J; Wray, NR; Lee, SH; Ripke, S; Neale, BM; Corvin, A; Walters, JTR; Farh, KH; Holmans, PA; Lee, P; Bulik-Sullivan, B; Collier, DA; Huang, H; Pers, TH; Agartz, I; Agerbo, E; Albus, M; Alexander, M; Amin, F; Bacanu, SA; Begemann, M; Belliveau, RA; Bene, J; Bergen, SE; Bevilacqua, E; Bigdeli, TB; Black, DW; Bruggeman, R; Buccola, NG; Buckner, RL; Byerley, W; Cahn, W; Cai, G; Campion, D; Cantor, RM; Carr, VJ; Carrera, N; Catts, SV; Chambert, KD; Chan, RCK; Chen, RYL; Chen, EYH; Cheng, W; Cheung, EFC; Chong, SA; Cloninger, CR; Cohen, D; Cohen, N; Cormican, P; Craddock, N; Crowley, JJ; Curtis, D; Davidson, M; Davis, KL; Degenhardt, F; Del Favero, J; Demontis, D; Dikeos, D; Dinan, T; Djurovic, S; Donohoe, G; Drapeau, E; Psychiatric Genomics Consortium, Schizophrenia Working Group, .; - view fewer <#> (2018) Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports , 8 , Article 10168. 10.1038/s41598-018-28160-z <https://doi.org/10.1038/s41598-018-28160-z>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10053030/1/s41598-018-28160-z.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10053030/7/41598_2018_28160_MOESM1_ESM.pdf