eprintid: 10053030
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/05/30/30
datestamp: 2018-07-25 13:08:23
lastmod: 2021-09-17 22:13:13
status_changed: 2018-07-25 13:08:23
type: article
metadata_visibility: show
creators_name: Ni, G
creators_name: Gratten, J
creators_name: Wray, NR
creators_name: Lee, SH
creators_name: Ripke, S
creators_name: Neale, BM
creators_name: Corvin, A
creators_name: Walters, JTR
creators_name: Farh, KH
creators_name: Holmans, PA
creators_name: Lee, P
creators_name: Bulik-Sullivan, B
creators_name: Collier, DA
creators_name: Huang, H
creators_name: Pers, TH
creators_name: Agartz, I
creators_name: Agerbo, E
creators_name: Albus, M
creators_name: Alexander, M
creators_name: Amin, F
creators_name: Bacanu, SA
creators_name: Begemann, M
creators_name: Belliveau, RA
creators_name: Bene, J
creators_name: Bergen, SE
creators_name: Bevilacqua, E
creators_name: Bigdeli, TB
creators_name: Black, DW
creators_name: Bruggeman, R
creators_name: Buccola, NG
creators_name: Buckner, RL
creators_name: Byerley, W
creators_name: Cahn, W
creators_name: Cai, G
creators_name: Campion, D
creators_name: Cantor, RM
creators_name: Carr, VJ
creators_name: Carrera, N
creators_name: Catts, SV
creators_name: Chambert, KD
creators_name: Chan, RCK
creators_name: Chen, RYL
creators_name: Chen, EYH
creators_name: Cheng, W
creators_name: Cheung, EFC
creators_name: Chong, SA
creators_name: Cloninger, CR
creators_name: Cohen, D
creators_name: Cohen, N
creators_name: Cormican, P
creators_name: Craddock, N
creators_name: Crowley, JJ
creators_name: Curtis, D
creators_name: Davidson, M
creators_name: Davis, KL
creators_name: Degenhardt, F
creators_name: Del Favero, J
creators_name: Demontis, D
creators_name: Dikeos, D
creators_name: Dinan, T
creators_name: Djurovic, S
creators_name: Donohoe, G
creators_name: Drapeau, E
creators_name: Psychiatric Genomics Consortium, Schizophrenia Working Group, .
title: Age at first birth in women is genetically associated with increased risk of schizophrenia
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
divisions: C08
divisions: D09
divisions: F99
note: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
abstract: Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
date: 2018
date_type: published
official_url: https://doi.org/10.1038/s41598-018-28160-z
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1568318
doi: 10.1038/s41598-018-28160-z
lyricists_name: Bramon, Elvira
lyricists_name: Curtis, David
lyricists_name: McQuillin, Andrew
lyricists_id: EBRAM47
lyricists_id: DCURT26
lyricists_id: AMCQU28
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Scientific Reports
volume: 8
article_number: 10168
issn: 2045-2322
citation:        Ni, G;    Gratten, J;    Wray, NR;    Lee, SH;    Ripke, S;    Neale, BM;    Corvin, A;                                                                                                                                                                                                                                     ... Psychiatric Genomics Consortium, Schizophrenia Working Group, .; + view all <#>        Ni, G;  Gratten, J;  Wray, NR;  Lee, SH;  Ripke, S;  Neale, BM;  Corvin, A;  Walters, JTR;  Farh, KH;  Holmans, PA;  Lee, P;  Bulik-Sullivan, B;  Collier, DA;  Huang, H;  Pers, TH;  Agartz, I;  Agerbo, E;  Albus, M;  Alexander, M;  Amin, F;  Bacanu, SA;  Begemann, M;  Belliveau, RA;  Bene, J;  Bergen, SE;  Bevilacqua, E;  Bigdeli, TB;  Black, DW;  Bruggeman, R;  Buccola, NG;  Buckner, RL;  Byerley, W;  Cahn, W;  Cai, G;  Campion, D;  Cantor, RM;  Carr, VJ;  Carrera, N;  Catts, SV;  Chambert, KD;  Chan, RCK;  Chen, RYL;  Chen, EYH;  Cheng, W;  Cheung, EFC;  Chong, SA;  Cloninger, CR;  Cohen, D;  Cohen, N;  Cormican, P;  Craddock, N;  Crowley, JJ;  Curtis, D;  Davidson, M;  Davis, KL;  Degenhardt, F;  Del Favero, J;  Demontis, D;  Dikeos, D;  Dinan, T;  Djurovic, S;  Donohoe, G;  Drapeau, E;  Psychiatric Genomics Consortium, Schizophrenia Working Group, .;   - view fewer <#>    (2018)    Age at first birth in women is genetically associated with increased risk of schizophrenia.                   Scientific Reports , 8     , Article 10168.  10.1038/s41598-018-28160-z <https://doi.org/10.1038/s41598-018-28160-z>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10053030/1/s41598-018-28160-z.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/10053030/7/41598_2018_28160_MOESM1_ESM.pdf