eprintid: 10052958 rev_number: 40 eprint_status: archive userid: 608 dir: disk0/10/05/29/58 datestamp: 2018-07-24 15:11:39 lastmod: 2021-09-20 22:26:20 status_changed: 2018-11-29 11:12:13 type: article metadata_visibility: show creators_name: Clout, AE creators_name: Buanz, ABM creators_name: Gaisford, S creators_name: Williams, G title: Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G08 keywords: Phase transitions, hyphenated techniques, pharmaceutical materials, synchrotron X-ray diffraction, thermal analysis note: This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: Temperature-induced phase transitions in carbamazepine (CBZ) and 1,10-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry - X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localized melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, by either a solid-solid pathway or a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I. date: 2018-09 date_type: published official_url: https://doi.org/10.1002/chem.201802368 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1570511 doi: 10.1002/chem.201802368 lyricists_name: Buanz, Asma lyricists_name: Clout, Alexander lyricists_name: Gaisford, Simon lyricists_name: Williams, Gareth lyricists_id: ABMBU27 lyricists_id: AECLO76 lyricists_id: SGAIS88 lyricists_id: GWILL02 actors_name: Stacey, Thomas actors_id: TSSTA20 actors_role: owner full_text_status: public publication: Chemistry - A European Journal volume: 24 number: 51 pagerange: 13573-13581 event_location: Germany issn: 1521-3765 citation: Clout, AE; Buanz, ABM; Gaisford, S; Williams, G; (2018) Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine. Chemistry - A European Journal , 24 (51) pp. 13573-13581. 10.1002/chem.201802368 <https://doi.org/10.1002/chem.201802368>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10052958/9/Clout_Polymorphic%20Phase%20Transitions%20in%20Carbamazepine%20and%2010%252C11-Dihydrocarbamazepine.pdf