TY  - JOUR
N1  - This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
KW  - Phase transitions
KW  -  hyphenated techniques
KW  -  pharmaceutical materials
KW  -  synchrotron X-ray diffraction
KW  -  thermal analysis
AV  - public
SN  - 1521-3765
TI  - Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine
EP  - 13581
IS  - 51
SP  - 13573
VL  - 24
A1  - Clout, AE
A1  - Buanz, ABM
A1  - Gaisford, S
A1  - Williams, G
JF  - Chemistry - A European Journal
Y1  - 2018/09//
ID  - discovery10052958
UR  - https://doi.org/10.1002/chem.201802368
N2  - Temperature-induced phase transitions in carbamazepine (CBZ) and 1,10-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry - X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localized melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, by either a solid-solid pathway or a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.
ER  -