@article{discovery10052958,
           month = {September},
          volume = {24},
            note = {This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.},
           pages = {13573--13581},
            year = {2018},
           title = {Polymorphic phase transitions in carbamazepine and 10,11-dihydrocarbamazepine},
          number = {51},
         journal = {Chemistry - A European Journal},
        keywords = {Phase transitions, hyphenated techniques, pharmaceutical materials, synchrotron X-ray diffraction, thermal analysis},
          author = {Clout, AE and Buanz, ABM and Gaisford, S and Williams, G},
             url = {https://doi.org/10.1002/chem.201802368},
        abstract = {Temperature-induced phase transitions in carbamazepine (CBZ) and 1,10-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry - X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localized melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 oC, by either a solid-solid pathway or a localised intermediate melt phase. CBZ form II converted to form I at 119 oC by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.},
            issn = {1521-3765}
}