eprintid: 10052660
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/05/26/60
datestamp: 2018-07-19 14:01:38
lastmod: 2021-12-05 00:41:19
status_changed: 2018-07-19 14:01:38
type: article
metadata_visibility: show
creators_name: Sankar, A
creators_name: Adams, TM
creators_name: Costafreda, SG
creators_name: Marangell, LB
creators_name: Fu, CH
title: Effects of antidepressant therapy on neural components of verbal working memory in depression
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
keywords: Cognition, Sternberg, antidepressant, executive function, Adult, Antidepressive Agents, Brain Mapping, Case-Control Studies, Depression, Depressive Disorder, Major, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory, Short-Term, Psychomotor Performance
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Impairments in verbal working memory are evident in major depression. Verbal working memory is comprised of the components of encoding, maintenance and retrieval. Whether the neural impairments are expressed in specific components, and how pharmacological therapy could modify the neural correlates are not well understood. We investigated the neural correlates of verbal working memory components in depression using the Sternberg task in a longitudinal magnetic resonance imaging study. Serial scans were acquired in 23 patients (mean age 39.8 years) during an acute depressive episode and following 12 weeks of pharmacological therapy with duloxetine and in 22 matched healthy controls (mean age 39.1 years) at the same time points. A significant group by time interaction was evident during the long maintenance phase, extending from the left middle frontal to the middle temporal and caudate regions, in which there was reduced activation in healthy participants at the follow -up scan but there were no changes in patients. Persistent neural engagement during the maintenance phase following treatment was revealed in major depression. The findings emphasize that impairments in verbal working memory may be initiated in the maintenance phase in major depression in order to sustain performance. Further research with larger sample size and using randomized, placebo-controlled double-blind studies are required to confirm our results.
date: 2017-08-31
date_type: published
official_url: https://doi.org/10.1177/0269881117724594
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1500867
doi: 10.1177/0269881117724594
lyricists_name: Costafreda Gonzalez, Sergi
lyricists_id: SCOST14
actors_name: Costafreda Gonzalez, Sergi
actors_id: SCOST14
actors_role: owner
full_text_status: public
publication: Journal of Psychopharmacology
volume: 31
number: 9
pagerange: 1176-1183
event_location: United States
issn: 1461-7285
citation:        Sankar, A;    Adams, TM;    Costafreda, SG;    Marangell, LB;    Fu, CH;      (2017)    Effects of antidepressant therapy on neural components of verbal working memory in depression.                   Journal of Psychopharmacology , 31  (9)   pp. 1176-1183.    10.1177/0269881117724594 <https://doi.org/10.1177/0269881117724594>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10052660/1/xManuscript_Psychopharmacology_version%20accepted.pdf