<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10052344> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/title> "Transcriptional memory of cells of origin overrides βâ€catenin requirement of MLL cancer stem cells"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/abstract> "While βâ€catenin has been demonstrated as an essential molecule and therapeutic target for various cancer stem cells (CSCs) including those driven by MLL fusions, here we show that transcriptional memory from cells of origin predicts AML patient survival and allows βâ€cateninâ€independent transformation in MLLâ€CSCs derived from hematopoietic stem cell (HSC)â€enriched LSK population but not myeloid–granulocyte progenitors. Mechanistically, βâ€catenin regulates expression of downstream targets of a key transcriptional memory gene, Hoxa9 that is highly enriched in LSKâ€derived MLLâ€CSCs and helps sustain leukemic selfâ€renewal. Suppression of Hoxa9 sensitizes LSKâ€derived MLLâ€CSCs to βâ€catenin inhibition resulting in abolishment of CSC transcriptional program and transformation ability. In addition, further molecular and functional analyses identified Prmt1 as a key common downstream mediator for βâ€catenin/Hoxa9 functions in LSKâ€derived MLLâ€CSCs. Together, these findings not only uncover an unexpectedly important role of cells of origin transcriptional memory in regulating CSC selfâ€renewal, but also reveal a novel molecular network mediated by βâ€catenin/Hoxa9/Prmt1 in governing leukemic selfâ€renewal."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/date> "2017-11-02" . <https://discovery.ucl.ac.uk/id/document/701473> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/volume> "36" . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/issue> "21" . <https://discovery.ucl.ac.uk/id/publication/ext-02614189> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-02614189> <http://xmlns.com/foaf/0.1/name> "The EMBO Journal"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-02614189> . <https://discovery.ucl.ac.uk/id/publication/ext-02614189> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:02614189> . <https://discovery.ucl.ac.uk/id/publication/ext-02614189> <http://purl.org/ontology/bibo/issn> "02614189" . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8dabd30c367ae802a1e55d54e920f110> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-8dabd30c367ae802a1e55d54e920f110> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-11e0d80bb0ad67ce6e271689645bfdf3> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-11e0d80bb0ad67ce6e271689645bfdf3> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65561e66552fecc0985e031ba0a8367b> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-65561e66552fecc0985e031ba0a8367b> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e929f1862aa98eead7455e68d240d402> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e929f1862aa98eead7455e68d240d402> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7be3f19d6763408f36974622ce27ee96> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-7be3f19d6763408f36974622ce27ee96> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-854ba7ba10d5bf2bf5804dfd775e4d55> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-854ba7ba10d5bf2bf5804dfd775e4d55> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2166ee6519ef34b5f67d6b92213f4384> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-2166ee6519ef34b5f67d6b92213f4384> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-73034e4e0996845bfae102acdadb15f3> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-73034e4e0996845bfae102acdadb15f3> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4cbf8a97519afac13df73e9be427bccf> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-4cbf8a97519afac13df73e9be427bccf> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-473c87ddae50abaeb040d3e06f383ed2> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-473c87ddae50abaeb040d3e06f383ed2> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-834afdc6d452d916ff3a5c9675d1370b> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-834afdc6d452d916ff3a5c9675d1370b> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e73af2ad2d5ec2883d42ccaff1bd15e9> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-e73af2ad2d5ec2883d42ccaff1bd15e9> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0486607b9164c994ddccce416d65da53> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-0486607b9164c994ddccce416d65da53> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d10a8430b29e13370ce7463675b23121> . <https://discovery.ucl.ac.uk/id/eprint/10052344> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> . <https://discovery.ucl.ac.uk/id/eprint/10052344#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-d10a8430b29e13370ce7463675b23121> . <https://discovery.ucl.ac.uk/id/person/ext-73034e4e0996845bfae102acdadb15f3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-73034e4e0996845bfae102acdadb15f3> <http://xmlns.com/foaf/0.1/givenName> "QC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73034e4e0996845bfae102acdadb15f3> <http://xmlns.com/foaf/0.1/familyName> "Hoang"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-73034e4e0996845bfae102acdadb15f3> <http://xmlns.com/foaf/0.1/name> "QC Hoang"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-834afdc6d452d916ff3a5c9675d1370b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-834afdc6d452d916ff3a5c9675d1370b> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-834afdc6d452d916ff3a5c9675d1370b> <http://xmlns.com/foaf/0.1/familyName> "Lynn"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-834afdc6d452d916ff3a5c9675d1370b> <http://xmlns.com/foaf/0.1/name> "C Lynn"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7be3f19d6763408f36974622ce27ee96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7be3f19d6763408f36974622ce27ee96> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7be3f19d6763408f36974622ce27ee96> <http://xmlns.com/foaf/0.1/familyName> "Mallardo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7be3f19d6763408f36974622ce27ee96> <http://xmlns.com/foaf/0.1/name> "M Mallardo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8dabd30c367ae802a1e55d54e920f110> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8dabd30c367ae802a1e55d54e920f110> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8dabd30c367ae802a1e55d54e920f110> <http://xmlns.com/foaf/0.1/familyName> "Siriboonpiputtana"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8dabd30c367ae802a1e55d54e920f110> <http://xmlns.com/foaf/0.1/name> "T Siriboonpiputtana"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d10a8430b29e13370ce7463675b23121> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-d10a8430b29e13370ce7463675b23121> <http://xmlns.com/foaf/0.1/givenName> "CWE"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d10a8430b29e13370ce7463675b23121> <http://xmlns.com/foaf/0.1/familyName> "So"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-d10a8430b29e13370ce7463675b23121> <http://xmlns.com/foaf/0.1/name> "CWE So"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4cbf8a97519afac13df73e9be427bccf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4cbf8a97519afac13df73e9be427bccf> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4cbf8a97519afac13df73e9be427bccf> <http://xmlns.com/foaf/0.1/familyName> "Veiga"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4cbf8a97519afac13df73e9be427bccf> <http://xmlns.com/foaf/0.1/name> "P Veiga"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-854ba7ba10d5bf2bf5804dfd775e4d55> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-854ba7ba10d5bf2bf5804dfd775e4d55> <http://xmlns.com/foaf/0.1/givenName> "CT"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-854ba7ba10d5bf2bf5804dfd775e4d55> <http://xmlns.com/foaf/0.1/familyName> "Tsai"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-854ba7ba10d5bf2bf5804dfd775e4d55> <http://xmlns.com/foaf/0.1/name> "CT Tsai"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-11e0d80bb0ad67ce6e271689645bfdf3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-11e0d80bb0ad67ce6e271689645bfdf3> <http://xmlns.com/foaf/0.1/givenName> "BB"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-11e0d80bb0ad67ce6e271689645bfdf3> <http://xmlns.com/foaf/0.1/familyName> "Zeisig"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-11e0d80bb0ad67ce6e271689645bfdf3> <http://xmlns.com/foaf/0.1/name> "BB Zeisig"^^<http://www.w3.org/2001/XMLSchema#string> . 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<https://discovery.ucl.ac.uk/id/person/ext-e73af2ad2d5ec2883d42ccaff1bd15e9> <http://xmlns.com/foaf/0.1/familyName> "Wilson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e73af2ad2d5ec2883d42ccaff1bd15e9> <http://xmlns.com/foaf/0.1/name> "A Wilson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0486607b9164c994ddccce416d65da53> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0486607b9164c994ddccce416d65da53> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0486607b9164c994ddccce416d65da53> <http://xmlns.com/foaf/0.1/familyName> "Lenhard"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0486607b9164c994ddccce416d65da53> <http://xmlns.com/foaf/0.1/name> "B Lenhard"^^<http://www.w3.org/2001/XMLSchema#string> 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