eprintid: 10052021 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/10/05/20/21 datestamp: 2018-07-09 17:45:50 lastmod: 2022-01-19 23:48:07 status_changed: 2018-07-09 17:45:50 type: article metadata_visibility: show creators_name: Stavrou, C creators_name: Wincup, C creators_name: Kravvas, G creators_name: Manson, J title: An atypical case of scleroderma ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Systemic sclerosis, or scleroderma is a rare systemic autoimmune rheumatic disease with an annual incidence of 3.7 per million in the UK. We report the case of a 55 year old female presenting with insidious onset weight loss, pruritus and worsening shortness of breath. Examination revealed signs of cardiac failure, fine inspiratory crepitations, hepatomegaly and diffuse cutaneous depigmentation although with minimal peripheral sclerodactyly. The anti-nuclear antibodies were interestingly negative and malignancy was not found on thorough screening. The patient was commenced on treatment with oral prednisone and intravenous cyclophosphamide for diffuse cutaneous systemic sclerosis. A rapid response in cardiac function, respiratory symptoms and fatigue was noted. In addition, skin texture rapidly improved with associated re-pigmentation seen within two weeks of commencing treatment. However, within two months of discharge the patient died. The cause of death was thought to be due to cardiac arrhythmia likely secondary to chronic myocarditis. date: 2017-10 date_type: published publisher: MA HEALTHCARE LTD official_url: https://doi.org/10.12968/hmed.2017.78.10.590 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1437009 doi: 10.12968/hmed.2017.78.10.590 lyricists_name: Wincup, Christopher lyricists_id: CWINC43 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: British Journal of Hospital Medicine volume: 78 number: 10 pagerange: 590-591 pages: 2 issn: 1759-7390 citation: Stavrou, C; Wincup, C; Kravvas, G; Manson, J; (2017) An atypical case of scleroderma. British Journal of Hospital Medicine , 78 (10) pp. 590-591. 10.12968/hmed.2017.78.10.590 <https://doi.org/10.12968/hmed.2017.78.10.590>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10052021/1/Wincup_Scleroderma%20case%20report.pdf