<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10051921> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/title> "CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/abstract> "INTRODUCTION: We studied whether fully automated Elecsys cerebrospinal fluid (CSF) immunoassay results were concordant with positron emission tomography (PET) and predicted clinical progression, even with cutoffs established in an independent cohort. METHODS: Cutoffs for Elecsys amyloid-β1-42 (Aβ), total tau/Aβ(1-42), and phosphorylated tau/Aβ(1-42) were defined against [18F]flutemetamol PET in Swedish BioFINDER (n = 277) and validated against [18F]florbetapir PET in Alzheimer's Disease Neuroimaging Initiative (n = 646). Clinical progression in patients with mild cognitive impairment (n = 619) was studied. RESULTS: CSF total tau/Aβ(1-42) and phosphorylated tau/Aβ(1-42) ratios were highly concordant with PET classification in BioFINDER (overall percent agreement: 90%; area under the curve: 94%). The CSF biomarker statuses established by predefined cutoffs were highly concordant with PET classification in Alzheimer's Disease Neuroimaging Initiative (overall percent agreement: 89%-90%; area under the curves: 96%) and predicted greater 2-year clinical decline in patients with mild cognitive impairment. Strikingly, tau/Aβ ratios were as accurate as semiquantitative PET image assessment in predicting visual read-based outcomes. DISCUSSION: Elecsys CSF biomarker assays may provide reliable alternatives to PET in Alzheimer's disease diagnosis."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/date> "2018-11" . <https://discovery.ucl.ac.uk/id/document/922604> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/document/699857> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/volume> "14" . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/issue> "11" . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://xmlns.com/foaf/0.1/name> "Alzheimer's & Dementia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-15525279> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:15525279> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://purl.org/ontology/bibo/issn> "15525279" . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-07a21d752bb34164dfed815ce27e0618> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-07a21d752bb34164dfed815ce27e0618> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1f721a6b67765e13f4c7b2d322bc79b1> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-1f721a6b67765e13f4c7b2d322bc79b1> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f4f904e575db3840d59dcd02dd5e69d0> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-f4f904e575db3840d59dcd02dd5e69d0> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-15b79e8231f071cd827388a4d6d0bec2> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-15b79e8231f071cd827388a4d6d0bec2> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e7d7a978bb15fc24584f7d0b8aba97ec> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-e7d7a978bb15fc24584f7d0b8aba97ec> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2c87e4085dac4162c122a6c42d848636> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-2c87e4085dac4162c122a6c42d848636> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9934ca852b17e028114795bddfe2e016> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-9934ca852b17e028114795bddfe2e016> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-150185d25172a649deb9c97ddd593758> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-150185d25172a649deb9c97ddd593758> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b893f30b3439fd308324e0f3f9fc71e6> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-b893f30b3439fd308324e0f3f9fc71e6> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d450680f17bb7f2483ce72120bce52e8> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d450680f17bb7f2483ce72120bce52e8> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e67e9dd14678f063a6437f8a399fb37c> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e67e9dd14678f063a6437f8a399fb37c> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5976a6748d7dcb9d6b83d35c6419b424> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-5976a6748d7dcb9d6b83d35c6419b424> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d45cde032819d6dcc37292213238c33f> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-d45cde032819d6dcc37292213238c33f> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-265b7fcc7117255a90a7e03d4d930146> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-265b7fcc7117255a90a7e03d4d930146> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1d1ae2aa1d16fc2265a85d04842b8836> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-1d1ae2aa1d16fc2265a85d04842b8836> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0b8fe4a02d78928a1e241bddf667ef62> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-0b8fe4a02d78928a1e241bddf667ef62> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0cfc83cb54d6fe62fc65bfce58749c96> . <https://discovery.ucl.ac.uk/id/eprint/10051921> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051921#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-0cfc83cb54d6fe62fc65bfce58749c96> . <https://discovery.ucl.ac.uk/id/person/ext-0cfc83cb54d6fe62fc65bfce58749c96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0cfc83cb54d6fe62fc65bfce58749c96> <http://xmlns.com/foaf/0.1/givenName> "."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0cfc83cb54d6fe62fc65bfce58749c96> <http://xmlns.com/foaf/0.1/familyName> "Alzheimer's Disease Neuroimaging Initiative"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0cfc83cb54d6fe62fc65bfce58749c96> <http://xmlns.com/foaf/0.1/name> ". Alzheimer's Disease Neuroimaging Initiative"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f4f904e575db3840d59dcd02dd5e69d0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f4f904e575db3840d59dcd02dd5e69d0> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f4f904e575db3840d59dcd02dd5e69d0> <http://xmlns.com/foaf/0.1/familyName> "Stomrud"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f4f904e575db3840d59dcd02dd5e69d0> <http://xmlns.com/foaf/0.1/name> "E Stomrud"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-07a21d752bb34164dfed815ce27e0618> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-07a21d752bb34164dfed815ce27e0618> <http://xmlns.com/foaf/0.1/givenName> "O"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-07a21d752bb34164dfed815ce27e0618> <http://xmlns.com/foaf/0.1/familyName> "Hansson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-07a21d752bb34164dfed815ce27e0618> <http://xmlns.com/foaf/0.1/name> "O Hansson"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d1ae2aa1d16fc2265a85d04842b8836> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1d1ae2aa1d16fc2265a85d04842b8836> <http://xmlns.com/foaf/0.1/givenName> "LM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d1ae2aa1d16fc2265a85d04842b8836> <http://xmlns.com/foaf/0.1/familyName> "Shaw"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d1ae2aa1d16fc2265a85d04842b8836> <http://xmlns.com/foaf/0.1/name> "LM Shaw"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1f721a6b67765e13f4c7b2d322bc79b1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1f721a6b67765e13f4c7b2d322bc79b1> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1f721a6b67765e13f4c7b2d322bc79b1> <http://xmlns.com/foaf/0.1/familyName> "Seibyl"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1f721a6b67765e13f4c7b2d322bc79b1> <http://xmlns.com/foaf/0.1/name> "J Seibyl"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b893f30b3439fd308324e0f3f9fc71e6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b893f30b3439fd308324e0f3f9fc71e6> <http://xmlns.com/foaf/0.1/givenName> "U"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b893f30b3439fd308324e0f3f9fc71e6> <http://xmlns.com/foaf/0.1/familyName> "Eichenlaub"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b893f30b3439fd308324e0f3f9fc71e6> <http://xmlns.com/foaf/0.1/name> "U Eichenlaub"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7d7a978bb15fc24584f7d0b8aba97ec> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e7d7a978bb15fc24584f7d0b8aba97ec> <http://xmlns.com/foaf/0.1/givenName> "JQ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7d7a978bb15fc24584f7d0b8aba97ec> <http://xmlns.com/foaf/0.1/familyName> "Trojanowski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7d7a978bb15fc24584f7d0b8aba97ec> <http://xmlns.com/foaf/0.1/name> "JQ Trojanowski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0b8fe4a02d78928a1e241bddf667ef62> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-0b8fe4a02d78928a1e241bddf667ef62> <http://xmlns.com/foaf/0.1/givenName> "."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0b8fe4a02d78928a1e241bddf667ef62> <http://xmlns.com/foaf/0.1/familyName> "Swedish BioFINDER study group"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-0b8fe4a02d78928a1e241bddf667ef62> <http://xmlns.com/foaf/0.1/name> ". Swedish BioFINDER study group"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5976a6748d7dcb9d6b83d35c6419b424> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5976a6748d7dcb9d6b83d35c6419b424> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5976a6748d7dcb9d6b83d35c6419b424> <http://xmlns.com/foaf/0.1/familyName> "Zink"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5976a6748d7dcb9d6b83d35c6419b424> <http://xmlns.com/foaf/0.1/name> "K Zink"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2c87e4085dac4162c122a6c42d848636> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2c87e4085dac4162c122a6c42d848636> 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