eprintid: 10051871
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/10/05/18/71
datestamp: 2018-07-11 12:55:41
lastmod: 2021-09-29 22:13:42
status_changed: 2018-07-11 12:55:41
type: article
metadata_visibility: show
creators_name: McGinnity, CJ
creators_name: Barros, DAR
creators_name: Trigg, W
creators_name: Brooks, DJ
creators_name: Hinz, R
creators_name: Duncan, JS
creators_name: Koepp, MJ
creators_name: Hammers, A
title: Simplifying [F-18]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F81
keywords: Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, NMDA, PET, Compartmental modelling, CNS-5161, SUV, RECEPTORS, BINDING, QUANTIFICATION
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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abstract: Introduction

The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.

Methods

For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs).

Results

Correlations with the original ppIF-derived 90-min VTs increased for later interval SUVs (maximal ρ = 0.78; 80–90 min). They were strong for PBIF-derived VTs (ρ = 0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived VTs (ρ = 0.97–1.00), which suffered regionally variant negative bias.

Conclusions

Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.
date: 2018-06-11
date_type: published
publisher: SPRINGER HEIDELBERG
official_url: https://doi.org/10.1186/s13550-018-0396-2
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1561753
doi: 10.1186/s13550-018-0396-2
lyricists_name: Duncan, John
lyricists_name: Koepp, Matthias
lyricists_id: JSDUN52
lyricists_id: MJKOE13
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: EJNMMI Research
volume: 8
article_number: 46
pages: 8
issn: 2191-219X
citation:        McGinnity, CJ;    Barros, DAR;    Trigg, W;    Brooks, DJ;    Hinz, R;    Duncan, JS;    Koepp, MJ;           McGinnity, CJ;  Barros, DAR;  Trigg, W;  Brooks, DJ;  Hinz, R;  Duncan, JS;  Koepp, MJ;  Hammers, A;   - view fewer <#>    (2018)    Simplifying [F-18]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?                   EJNMMI Research , 8     , Article 46.  10.1186/s13550-018-0396-2 <https://doi.org/10.1186/s13550-018-0396-2>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10051871/1/s13550-018-0396-2.pdf