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TI  - Simplifying [F-18]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?
EP  - 8
VL  - 8
AV  - public
Y1  - 2018/06/11/
JF  - EJNMMI Research
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Radiology
KW  -  Nuclear Medicine & Medical Imaging
KW  -  NMDA
KW  -  PET
KW  -  Compartmental modelling
KW  -  CNS-5161
KW  -  SUV
KW  -  RECEPTORS
KW  -  BINDING
KW  -  QUANTIFICATION
A1  - McGinnity, CJ
A1  - Barros, DAR
A1  - Trigg, W
A1  - Brooks, DJ
A1  - Hinz, R
A1  - Duncan, JS
A1  - Koepp, MJ
A1  - Hammers, A
ID  - discovery10051871
N2  - Introduction

The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible.

Methods

For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) over eight intervals; (2) volume of distribution (VT) images using population-based input functions (PBIFs), scaled using one parent plasma sample; and (3) VT images using three shortened datasets, using the original parent plasma input functions (ppIFs).

Results

Correlations with the original ppIF-derived 90-min VTs increased for later interval SUVs (maximal ??=?0.78; 80?90 min). They were strong for PBIF-derived VTs (??=?0.90), but between-subject coefficient of variation increased. Correlations were very strong for the 60/70/80-min original ppIF-derived VTs (??=?0.97?1.00), which suffered regionally variant negative bias.

Conclusions

Where arterial blood sampling is available, reduction of scan duration to 60 min is feasible, but with negative bias. The performance of SUVs was more consistent across participants than PBIF-derived VTs.
SN  - 2191-219X
PB  - SPRINGER HEIDELBERG
UR  - https://doi.org/10.1186/s13550-018-0396-2
ER  -