eprintid: 10051841 rev_number: 18 eprint_status: archive userid: 608 dir: disk0/10/05/18/41 datestamp: 2018-07-09 13:58:32 lastmod: 2021-09-26 22:20:09 status_changed: 2018-07-09 13:58:32 type: article metadata_visibility: show creators_name: Bjorefeldt, A creators_name: Illes, S creators_name: Zetterberg, H creators_name: Hanse, E title: Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: cerebrospinal fluid, neuromodulation, neural circuit note: Copyright © 2018 Bjorefeldt, Illes, Zetterberg and Hanse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. abstract: The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits in vivo via volume transmission. Recent in vitro experimental work in brain slices and neuronal cultures has shown that human CSF indeed contains neuromodulators that strongly influence neuronal activity. Here we briefly summarize these new findings and discuss their potential relevance to neural circuits in health and disease. date: 2018-02 date_type: published publisher: FRONTIERS MEDIA SA official_url: https://doi.org/10.3389/fncir.2018.00005 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Review verified: verified_manual elements_id: 1538505 doi: 10.3389/fncir.2018.00005 lyricists_name: Zetterberg, Henrik lyricists_id: HZETT94 actors_name: Waragoda Vitharana, Nimal actors_id: NWARR44 actors_role: owner full_text_status: public publication: Frontiers in Neural Circuits volume: 12 article_number: 5 pages: 12 issn: 1662-5110 citation: Bjorefeldt, A; Illes, S; Zetterberg, H; Hanse, E; (2018) Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies. Frontiers in Neural Circuits , 12 , Article 5. 10.3389/fncir.2018.00005 <https://doi.org/10.3389/fncir.2018.00005>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10051841/1/fncir-12-00005.pdf