eprintid: 10051841
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/05/18/41
datestamp: 2018-07-09 13:58:32
lastmod: 2021-09-26 22:20:09
status_changed: 2018-07-09 13:58:32
type: article
metadata_visibility: show
creators_name: Bjorefeldt, A
creators_name: Illes, S
creators_name: Zetterberg, H
creators_name: Hanse, E
title: Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: cerebrospinal fluid, neuromodulation, neural circuit
note: Copyright © 2018 Bjorefeldt, Illes, Zetterberg and Hanse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
abstract: The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space
and, together with the interstitial fluid (ISF), forms a continuous fluidic network that
bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned
to actively distribute neuromodulators to neural circuits in vivo via volume transmission.
Recent in vitro experimental work in brain slices and neuronal cultures has shown that
human CSF indeed contains neuromodulators that strongly influence neuronal activity.
Here we briefly summarize these new findings and discuss their potential relevance to
neural circuits in health and disease.
date: 2018-02
date_type: published
publisher: FRONTIERS MEDIA SA
official_url: https://doi.org/10.3389/fncir.2018.00005
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1538505
doi: 10.3389/fncir.2018.00005
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Frontiers in Neural Circuits
volume: 12
article_number: 5
pages: 12
issn: 1662-5110
citation:        Bjorefeldt, A;    Illes, S;    Zetterberg, H;    Hanse, E;      (2018)    Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies.                   Frontiers in Neural Circuits , 12     , Article 5.  10.3389/fncir.2018.00005 <https://doi.org/10.3389/fncir.2018.00005>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10051841/1/fncir-12-00005.pdf