TY  - JOUR
AV  - public
SN  - 1662-5110
A1  - Bjorefeldt, A
A1  - Illes, S
A1  - Zetterberg, H
A1  - Hanse, E
KW  - cerebrospinal fluid
KW  -  neuromodulation
KW  -  neural circuit
N2  - The cerebrospinal fluid (CSF) occupies the brain?s ventricles and subarachnoid space
and, together with the interstitial fluid (ISF), forms a continuous fluidic network that
bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned
to actively distribute neuromodulators to neural circuits in vivo via volume transmission.
Recent in vitro experimental work in brain slices and neuronal cultures has shown that
human CSF indeed contains neuromodulators that strongly influence neuronal activity.
Here we briefly summarize these new findings and discuss their potential relevance to
neural circuits in health and disease.
EP  - 12
JF  - Frontiers in Neural Circuits
VL  - 12
PB  - FRONTIERS MEDIA SA
ID  - discovery10051841
Y1  - 2018/02//
UR  - https://doi.org/10.3389/fncir.2018.00005
TI  - Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies
N1  - Copyright © 2018 Bjorefeldt, Illes, Zetterberg and Hanse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
ER  -