%0 Journal Article
%@ 1662-5110
%A Bjorefeldt, A
%A Illes, S
%A Zetterberg, H
%A Hanse, E
%D 2018
%F discovery:10051841
%I FRONTIERS MEDIA SA
%J Frontiers in Neural Circuits
%K cerebrospinal fluid, neuromodulation, neural circuit
%T Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies
%U https://discovery.ucl.ac.uk/id/eprint/10051841/
%V 12
%X The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space  and, together with the interstitial fluid (ISF), forms a continuous fluidic network that  bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned  to actively distribute neuromodulators to neural circuits in vivo via volume transmission.  Recent in vitro experimental work in brain slices and neuronal cultures has shown that  human CSF indeed contains neuromodulators that strongly influence neuronal activity.  Here we briefly summarize these new findings and discuss their potential relevance to  neural circuits in health and disease.
%Z Copyright © 2018 Bjorefeldt, Illes, Zetterberg and Hanse. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.