eprintid: 10051443
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/05/14/43
datestamp: 2018-07-03 14:19:47
lastmod: 2021-10-23 22:49:01
status_changed: 2018-07-03 14:19:47
type: article
metadata_visibility: show
creators_name: Zettergren, A
creators_name: Kern, S
creators_name: Ryden, L
creators_name: Ostling, S
creators_name: Blennow, K
creators_name: Zetterberg, H
creators_name: Falk, H
creators_name: Skoog, I
title: Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Longevity, Single nucleotide polymorphism, Cardiovascular disease, Dementia, Depression
note: Copyright © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
abstract: Self-rated health (SRH) strongly predicts mortality. Twin studies estimate that genetic factors account for a substantial part of the variability in SRH. Variations in the gene FOXO3 (forkhead box O3), and in genes located at the APOE (apoplipoprotein E) locus, are associated with longevity. This study explores the relationship between SRH and genetic variation related to longevity, in a population-based cohort of older individuals. SRH was assessed among 1,520 individuals aged 75–87, and five single nucleotide polymorphisms (SNPs), in APOE, TOMM40 (translocase of outer mitochondrial membrane 40 homolog), and FOXO3 were genotyped. Two SNPs (rs10457180 and rs2802292) in FOXO3 were associated with SRH (OR = 2.18 [CI: 1.27–3.76], p = .005 and OR = 1.63 [CI: 1.11–2.40], p = .013), while no associations were found with SNPs in APOE and TOMM40. Several factors, such as depression, cardiovascular disease (CVD), and diabetes, were related to SRH, but the only factor that had any influence on the association with FOXO3 was CVD. Still, after including CVD as a covariate, the associations between FOXO3 SNPs and SRH remained significant. Our results suggest that FOXO3 is related to SRH in older individuals. This relationship seems to be influenced by CVD, but not by mental and cognitive status.
date: 2018-11
date_type: published
publisher: OXFORD UNIV PRESS INC
official_url: https://doi.org/10.1093/gerona/gly021
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1534128
doi: 10.1093/gerona/gly021
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
volume: 73
number: 11
pagerange: 1453-1458
pages: 6
issn: 1758-535X
citation:        Zettergren, A;    Kern, S;    Ryden, L;    Ostling, S;    Blennow, K;    Zetterberg, H;    Falk, H;           Zettergren, A;  Kern, S;  Ryden, L;  Ostling, S;  Blennow, K;  Zetterberg, H;  Falk, H;  Skoog, I;   - view fewer <#>    (2018)    Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals.                   The Journals of Gerontology Series A: Biological Sciences and Medical Sciences , 73  (11)   pp. 1453-1458.    10.1093/gerona/gly021 <https://doi.org/10.1093/gerona%2Fgly021>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10051443/1/gly021.pdf