TY  - JOUR
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Psychiatry
KW  -  Alzheimer's disease
KW  -  dementia
KW  -  biomarkers
KW  -  cerebrospinal fluid
KW  -  consensus
KW  -  MILD COGNITIVE IMPAIRMENT
KW  -  AMYOTROPHIC-LATERAL-SCLEROSIS
KW  -  CREUTZFELDT-JAKOB-DISEASE
KW  -  CEREBRAL AMYLOID ANGIOPATHY
KW  -  FRONTOTEMPORAL LOBAR DEGENERATION
KW  -  PRECLINICAL ALZHEIMERS-DISEASE
KW  -  NEUROFILAMENT LIGHT-CHAIN
KW  -  POSITRON-EMISSION-TOMOGRAPHY
KW  -  GAMMA-SECRETASE INHIBITOR
KW  -  GENOME-WIDE ASSOCIATION
PB  - TAYLOR & FRANCIS LTD
ID  - discovery10051422
N2  - In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer?s disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-? positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.
EP  - 328
Y1  - 2018/01/01/
AV  - public
TI  - Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
A1  - Lewczuk, P
A1  - Riederer, P
A1  - O'Bryant, SE
A1  - Verbeek, MM
A1  - Dubois, B
A1  - Visser, PJ
A1  - Jellinger, KA
A1  - Engelborghs, S
A1  - Ramirez, A
A1  - Parnetti, L
A1  - Jack, CR
A1  - Teunissen, CE
A1  - Hampel, H
A1  - Lleo, A
A1  - Jessen, F
A1  - Glodzik, L
A1  - de Leon, MJ
A1  - Fagan, AM
A1  - Luis Molinuevo, J
A1  - Jansen, WJ
A1  - Winblad, B
A1  - Shaw, LM
A1  - Andreasson, U
A1  - Otto, M
A1  - Mollenhauer, B
A1  - Wiltfang, J
A1  - Turner, MR
A1  - Zerr, I
A1  - Handels, R
A1  - Thompson, AG
A1  - Johansson, G
A1  - Ermann, N
A1  - Trojanowski, JQ
A1  - Karaca, I
A1  - Wagner, H
A1  - Oeckl, P
A1  - van Doorn, LVW
A1  - Bjerke, M
A1  - Kapogiannis, D
A1  - Kuiperij, HB
A1  - Farotti, L
A1  - Li, Y
A1  - Gordon, BA
A1  - Epelbaum, S
A1  - Vos, SJB
A1  - Klijn, CJM
A1  - Van Nostrand, WE
A1  - Minguillon, C
A1  - Schmitz, M
A1  - Gallo, C
A1  - Mato, AL
A1  - Thibaut, F
A1  - Lista, S
A1  - Alcolea, D
A1  - Zetterberg, H
A1  - Blennow, K
A1  - Kornhuber, J
JF  - The World Journal of Biological Psychiatry
SN  - 1814-1412
UR  - http://dx.doi.org/10.1080/15622975.2017.1375556
N1  - © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/bync-nd/4.0/),
which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed,
or built upon in any way.
IS  - 4
VL  - 19
SP  - 244
ER  -