@article{discovery10051422,
       publisher = {TAYLOR \& FRANCIS LTD},
         journal = {The World Journal of Biological Psychiatry},
           pages = {244--328},
           title = {Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry},
            note = {{\copyright} 2017 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/bync-nd/4.0/),
which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed,
or built upon in any way.},
          volume = {19},
            year = {2018},
          number = {4},
           month = {January},
          author = {Lewczuk, P and Riederer, P and O'Bryant, SE and Verbeek, MM and Dubois, B and Visser, PJ and Jellinger, KA and Engelborghs, S and Ramirez, A and Parnetti, L and Jack, CR and Teunissen, CE and Hampel, H and Lleo, A and Jessen, F and Glodzik, L and de Leon, MJ and Fagan, AM and Luis Molinuevo, J and Jansen, WJ and Winblad, B and Shaw, LM and Andreasson, U and Otto, M and Mollenhauer, B and Wiltfang, J and Turner, MR and Zerr, I and Handels, R and Thompson, AG and Johansson, G and Ermann, N and Trojanowski, JQ and Karaca, I and Wagner, H and Oeckl, P and van Doorn, LVW and Bjerke, M and Kapogiannis, D and Kuiperij, HB and Farotti, L and Li, Y and Gordon, BA and Epelbaum, S and Vos, SJB and Klijn, CJM and Van Nostrand, WE and Minguillon, C and Schmitz, M and Gallo, C and Mato, AL and Thibaut, F and Lista, S and Alcolea, D and Zetterberg, H and Blennow, K and Kornhuber, J},
        abstract = {In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-{\ensuremath{\beta}} positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.},
        keywords = {Science \& Technology, Life Sciences \& Biomedicine, Psychiatry, Alzheimer's disease, dementia, biomarkers, cerebrospinal fluid, consensus, MILD COGNITIVE IMPAIRMENT, AMYOTROPHIC-LATERAL-SCLEROSIS, CREUTZFELDT-JAKOB-DISEASE, CEREBRAL AMYLOID ANGIOPATHY, FRONTOTEMPORAL LOBAR DEGENERATION, PRECLINICAL ALZHEIMERS-DISEASE, NEUROFILAMENT LIGHT-CHAIN, POSITRON-EMISSION-TOMOGRAPHY, GAMMA-SECRETASE INHIBITOR, GENOME-WIDE ASSOCIATION},
             url = {http://dx.doi.org/10.1080/15622975.2017.1375556},
            issn = {1814-1412}
}