<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10051349> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/title> "Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/abstract> "Iron is suggested to play a detrimental role in the progression of chronic kidney disease (CKD). The kidney recycles iron back into the circulation. However, the localization of proteins relevant for physiological tubular iron handling and their potential role in CKD remain unclear. We examined associations between iron deposition, expression of iron handling proteins and tubular injury in kidney biopsies from CKD patients and healthy controls using immunohistochemistry. Iron was deposited in proximal (PT) and distal tubules (DT) in 33% of CKD biopsies, predominantly in pathologies with glomerular dysfunction, but absent in controls. In healthy kidney, PT contained proteins required for iron recycling including putative iron importers ZIP8, ZIP14, DMT1, iron storage proteins L- and H-ferritin and iron exporter ferroportin, while DT only contained ZIP8, ZIP14, and DMT1. In CKD, iron deposition associated with increased intensity of iron importers (ZIP14, ZIP8), storage proteins (L-, H-ferritin), and/or decreased ferroportin abundance. This demonstrates that tubular iron accumulation may result from increased iron uptake and/or inadequate iron export. Iron deposition associated with oxidative injury as indicated by heme oxygenase-1 abundance. In conclusion, iron deposition is relatively common in CKD, and may result from altered molecular iron handling and may contribute to renal injury."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/date> "2018-06" . <https://discovery.ucl.ac.uk/id/document/691076> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/document/691989> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/volume> "8" . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20452322> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20452322> . <https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://purl.org/ontology/bibo/issn> "20452322" . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-24284b86e92c22f5f6e50cd8840f769a> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-24284b86e92c22f5f6e50cd8840f769a> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a86303a9306c5ad376fbb688c59d952e> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-a86303a9306c5ad376fbb688c59d952e> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-caedbe99d7a4a9093bdfa82c0f1378bc> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-caedbe99d7a4a9093bdfa82c0f1378bc> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-313e531f729e77d2e26522af9bd413cf> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-313e531f729e77d2e26522af9bd413cf> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c0c16c54ef083c4cb0b11efb2d21a3e7> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-c0c16c54ef083c4cb0b11efb2d21a3e7> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e5745e9ad0c2059e1700a54face0633e> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-e5745e9ad0c2059e1700a54face0633e> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-14dc643c56cc76656415affb389b74e9> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-14dc643c56cc76656415affb389b74e9> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8cc59d2de5d55c1d2dacb85e347e427e> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-8cc59d2de5d55c1d2dacb85e347e427e> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5ca211335c1460a5f9a3e4184f3b3a3a> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-5ca211335c1460a5f9a3e4184f3b3a3a> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c1d5abe13175239ef212ba08c78dae05> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-c1d5abe13175239ef212ba08c78dae05> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-815c2c3348619925a62af8a419064fe8> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-815c2c3348619925a62af8a419064fe8> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6dd13ef0760e700d5f94423ef78b9b16> . <https://discovery.ucl.ac.uk/id/eprint/10051349> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> . <https://discovery.ucl.ac.uk/id/eprint/10051349#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-6dd13ef0760e700d5f94423ef78b9b16> . <https://discovery.ucl.ac.uk/id/person/ext-c1d5abe13175239ef212ba08c78dae05> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c1d5abe13175239ef212ba08c78dae05> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c1d5abe13175239ef212ba08c78dae05> <http://xmlns.com/foaf/0.1/familyName> "Unwin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c1d5abe13175239ef212ba08c78dae05> <http://xmlns.com/foaf/0.1/name> "R Unwin"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5ca211335c1460a5f9a3e4184f3b3a3a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5ca211335c1460a5f9a3e4184f3b3a3a> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5ca211335c1460a5f9a3e4184f3b3a3a> <http://xmlns.com/foaf/0.1/familyName> "van Goor"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5ca211335c1460a5f9a3e4184f3b3a3a> <http://xmlns.com/foaf/0.1/name> "H van Goor"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-815c2c3348619925a62af8a419064fe8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-815c2c3348619925a62af8a419064fe8> <http://xmlns.com/foaf/0.1/givenName> "SK"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-815c2c3348619925a62af8a419064fe8> <http://xmlns.com/foaf/0.1/familyName> "Srai"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-815c2c3348619925a62af8a419064fe8> <http://xmlns.com/foaf/0.1/name> "SK Srai"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a86303a9306c5ad376fbb688c59d952e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-a86303a9306c5ad376fbb688c59d952e> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a86303a9306c5ad376fbb688c59d952e> <http://xmlns.com/foaf/0.1/familyName> "van Swelm"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-a86303a9306c5ad376fbb688c59d952e> <http://xmlns.com/foaf/0.1/name> "R van Swelm"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-24284b86e92c22f5f6e50cd8840f769a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-24284b86e92c22f5f6e50cd8840f769a> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-24284b86e92c22f5f6e50cd8840f769a> <http://xmlns.com/foaf/0.1/familyName> "van Raaij"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-24284b86e92c22f5f6e50cd8840f769a> <http://xmlns.com/foaf/0.1/name> "S van Raaij"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-caedbe99d7a4a9093bdfa82c0f1378bc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-caedbe99d7a4a9093bdfa82c0f1378bc> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-caedbe99d7a4a9093bdfa82c0f1378bc> <http://xmlns.com/foaf/0.1/familyName> "Bouman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-caedbe99d7a4a9093bdfa82c0f1378bc> <http://xmlns.com/foaf/0.1/name> "K Bouman"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8cc59d2de5d55c1d2dacb85e347e427e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8cc59d2de5d55c1d2dacb85e347e427e> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8cc59d2de5d55c1d2dacb85e347e427e> <http://xmlns.com/foaf/0.1/familyName> "Bass"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8cc59d2de5d55c1d2dacb85e347e427e> <http://xmlns.com/foaf/0.1/name> "P Bass"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-313e531f729e77d2e26522af9bd413cf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-313e531f729e77d2e26522af9bd413cf> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-313e531f729e77d2e26522af9bd413cf> <http://xmlns.com/foaf/0.1/familyName> "Cliteur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-313e531f729e77d2e26522af9bd413cf> <http://xmlns.com/foaf/0.1/name> "M Cliteur"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c0c16c54ef083c4cb0b11efb2d21a3e7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c0c16c54ef083c4cb0b11efb2d21a3e7> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c0c16c54ef083c4cb0b11efb2d21a3e7> <http://xmlns.com/foaf/0.1/familyName> "van den Heuvel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c0c16c54ef083c4cb0b11efb2d21a3e7> <http://xmlns.com/foaf/0.1/name> "M van den Heuvel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6dd13ef0760e700d5f94423ef78b9b16> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6dd13ef0760e700d5f94423ef78b9b16> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6dd13ef0760e700d5f94423ef78b9b16> <http://xmlns.com/foaf/0.1/familyName> "Swinkels"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6dd13ef0760e700d5f94423ef78b9b16> <http://xmlns.com/foaf/0.1/name> "D Swinkels"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e5745e9ad0c2059e1700a54face0633e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e5745e9ad0c2059e1700a54face0633e> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e5745e9ad0c2059e1700a54face0633e> <http://xmlns.com/foaf/0.1/familyName> "Pertijs"^^<http://www.w3.org/2001/XMLSchema#string> . 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