eprintid: 10051252
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/05/12/52
datestamp: 2018-07-02 11:54:05
lastmod: 2021-10-12 21:57:58
status_changed: 2018-07-02 11:54:05
type: article
metadata_visibility: show
creators_name: Breslin, K
creators_name: Wade, JJ
creators_name: Wong-Lin, KF
creators_name: Harkin, J
creators_name: Flanagan, B
creators_name: Van Zalinge, H
creators_name: Hall, S
creators_name: Walker, M
creators_name: Verkhratsky, A
creators_name: McDaid, L
title: Potassium and sodium microdomains in thin astroglial processes: A computational model study
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F81
note: Copyright © 2018 Breslin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
abstract: A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to “hopping” between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC. We further propose that a K+microdomain formed at the PsC, provides the driving force for the return of K+to the extracellular space for uptake by the neurone, thereby preventing K+undershoot. A slow decay of Na+was also observed in our simulation after a period of glutamate stimulation which is in strong agreement with experimental observations. The pathological implications of microdomain formation during neuronal excitation are also discussed.
date: 2018-05
date_type: published
official_url: https://doi.org/10.1371/journal.pcbi.1006151
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1563926
doi: 10.1371/journal.pcbi.1006151
lyricists_name: Walker, Matthew
lyricists_id: MCWAL61
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: PLoS Computational Biology
volume: 14
number: 5
article_number: e1006151
issn: 1553-7358
citation:        Breslin, K;    Wade, JJ;    Wong-Lin, KF;    Harkin, J;    Flanagan, B;    Van Zalinge, H;    Hall, S;             ... McDaid, L; + view all <#>        Breslin, K;  Wade, JJ;  Wong-Lin, KF;  Harkin, J;  Flanagan, B;  Van Zalinge, H;  Hall, S;  Walker, M;  Verkhratsky, A;  McDaid, L;   - view fewer <#>    (2018)    Potassium and sodium microdomains in thin astroglial processes: A computational model study.                   PLoS Computational Biology , 14  (5)    , Article e1006151.  10.1371/journal.pcbi.1006151 <https://doi.org/10.1371/journal.pcbi.1006151>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10051252/1/journal.pcbi.1006151.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/10051252/6/pcbi.1006151.suppl.pdf