eprintid: 10051252 rev_number: 28 eprint_status: archive userid: 608 dir: disk0/10/05/12/52 datestamp: 2018-07-02 11:54:05 lastmod: 2021-10-12 21:57:58 status_changed: 2018-07-02 11:54:05 type: article metadata_visibility: show creators_name: Breslin, K creators_name: Wade, JJ creators_name: Wong-Lin, KF creators_name: Harkin, J creators_name: Flanagan, B creators_name: Van Zalinge, H creators_name: Hall, S creators_name: Walker, M creators_name: Verkhratsky, A creators_name: McDaid, L title: Potassium and sodium microdomains in thin astroglial processes: A computational model study ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F81 note: Copyright © 2018 Breslin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. abstract: A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to “hopping” between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC. We further propose that a K+microdomain formed at the PsC, provides the driving force for the return of K+to the extracellular space for uptake by the neurone, thereby preventing K+undershoot. A slow decay of Na+was also observed in our simulation after a period of glutamate stimulation which is in strong agreement with experimental observations. The pathological implications of microdomain formation during neuronal excitation are also discussed. date: 2018-05 date_type: published official_url: https://doi.org/10.1371/journal.pcbi.1006151 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1563926 doi: 10.1371/journal.pcbi.1006151 lyricists_name: Walker, Matthew lyricists_id: MCWAL61 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: PLoS Computational Biology volume: 14 number: 5 article_number: e1006151 issn: 1553-7358 citation: Breslin, K; Wade, JJ; Wong-Lin, KF; Harkin, J; Flanagan, B; Van Zalinge, H; Hall, S; ... McDaid, L; + view all <#> Breslin, K; Wade, JJ; Wong-Lin, KF; Harkin, J; Flanagan, B; Van Zalinge, H; Hall, S; Walker, M; Verkhratsky, A; McDaid, L; - view fewer <#> (2018) Potassium and sodium microdomains in thin astroglial processes: A computational model study. PLoS Computational Biology , 14 (5) , Article e1006151. 10.1371/journal.pcbi.1006151 <https://doi.org/10.1371/journal.pcbi.1006151>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10051252/1/journal.pcbi.1006151.pdf document_url: https://discovery.ucl.ac.uk/id/eprint/10051252/6/pcbi.1006151.suppl.pdf