eprintid: 10051208
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/05/12/08
datestamp: 2018-06-29 11:40:36
lastmod: 2021-09-25 23:18:33
status_changed: 2018-06-29 11:40:36
type: article
metadata_visibility: show
creators_name: Rajaram, A
creators_name: Bale, G
creators_name: Kewin, M
creators_name: Morrison, LB
creators_name: Tachtsidis, I
creators_name: Lawrence, KS
creators_name: Diop, M
title: Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F42
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abstract: Preterm infants born with very low birth weights are at a high risk of brain injury, in part because the premature brain is believed to be prone to periods of low cerebral blood flow (CBF). Tissue damage is likely to occur if reduction in CBF is sufficient to impair cerebral energy metabolism for extended periods. Therefore, a neuromonitoring method that can detect reductions in CBF, large enough to affect metabolism, could alert the neonatal intensive care team before injury occurs. In this report, we present the development of an optical system that combines diffuse correlation spectroscopy (DCS) for monitoring CBF and broadband near-infrared spectroscopy (B-NIRS) for monitoring the oxidation state of cytochrome c oxidase (oxCCO) – a key biomarker of oxidative metabolism. The hybrid instrument includes a multiplexing system to enable concomitant DCS and B-NIRS measurements while avoiding crosstalk between the two subsystems. The ability of the instrument to monitor dynamic changes in CBF and oxCCO was demonstrated in a piglet model of neonatal hypoxia-ischemia (HI). Experiments conducted in eight animals, including two controls, showed that oxCCO exhibited a delayed response to ischemia while CBF and tissue oxygenation (StO2) responses were instantaneous. These findings suggest that simultaneous neuromonitoring of perfusion and metabolism could provide critical information regarding clinically significant hemodynamic events prior to the onset of brain injury.
date: 2018-05-10
date_type: published
official_url: https://doi.org/10.1364/BOE.9.002588
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1563574
doi: 10.1364/BOE.9.002588
lyricists_name: Bale, Gemma
lyricists_name: Tachtsidis, Ilias
lyricists_id: GMBAL14
lyricists_id: ITACH19
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Biomedical Optics Express
volume: 9
number: 6
pagerange: 2588-2603
issn: 2156-7085
citation:        Rajaram, A;    Bale, G;    Kewin, M;    Morrison, LB;    Tachtsidis, I;    Lawrence, KS;    Diop, M;      (2018)    Simultaneous monitoring of cerebral perfusion and cytochrome c oxidase by combining broadband near-infrared spectroscopy and diffuse correlation spectroscopy.                   Biomedical Optics Express , 9  (6)   pp. 2588-2603.    10.1364/BOE.9.002588 <https://doi.org/10.1364/BOE.9.002588>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10051208/1/boe-9-6-2588.pdf