eprintid: 10050950 rev_number: 29 eprint_status: archive userid: 608 dir: disk0/10/05/09/50 datestamp: 2018-06-25 10:11:54 lastmod: 2021-09-28 22:18:59 status_changed: 2019-06-24 14:05:46 type: article metadata_visibility: show creators_name: Hayes, JF creators_name: Picot, S creators_name: Osborn, DPJ creators_name: Lewis, G creators_name: Dalman, C creators_name: Lundin, A title: Visual Acuity in Late Adolescence and Future Psychosis Risk in a Cohort of 1 Million Men ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 keywords: eyesight, vision, schizophrenia, sibling-design note: Copyright © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Background: We aimed to determine whether late adolescent visual impairment is associated with later psychosis. // Methods: We conducted a longitudinal cohort study of Swedish male military conscripts aged 18 or 19 years from January 1, 1974, through December 31, 1997 (N = 1140710). At conscription, uncorrected and optometry-lens-corrected distance visual acuity was measured. Participants were then followed up to see if they received an inpatient diagnosis of non-affective psychotic disorder, including schizophrenia (N = 10769). Multivariable Cox modeling was used to estimate differences between groups. // Results: After adjustment for confounders, those with severe impairment before optical correction in their best eye (decimal fraction <0.3) had an increased psychosis rate compared to those with normal uncorrected vision (decimal fraction 1.0) (hazard ratio [HR] 1.26, 95% CI 1.16–1.37). Larger interocular visual acuity difference was associated with an increased psychosis rate (adjusted HR 1.49, 95% CI 1.37–1.63 in those with differences >0.5 compared to those with no between eye acuity difference). Individuals with impaired vision that could not be corrected to normal with lenses had highest rates of psychosis (best eye adjusted HR 1.56; 95% CI 1.33–1.82), those with imperfect, but correctable vision also had elevated rates (best eye adjusted HR 1.21; 95% CI 1.15–1.28). Individuals with visual impairment had higher rates of psychosis than their full siblings with normal vision (adjusted HR 1.20, 95% CI 1.07–1.35). // Conclusions: Impaired visual acuity is associated with non-affective psychosis. Visual impairment as a phenotype in psychosis requires further consideration. date: 2019-05 date_type: published official_url: https://doi.org/10.1093/schbul/sby084 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1562336 doi: 10.1093/schbul/sby084 pii: 5036511 lyricists_name: Hayes, Joseph lyricists_name: Lewis, Glyn lyricists_name: Osborn, David lyricists_id: JFHAY18 lyricists_id: GHLEW69 lyricists_id: DPJOS02 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Schizophrenia Bulletin volume: 45 number: 3 pagerange: 571-578 event_location: United States issn: 1745-1701 citation: Hayes, JF; Picot, S; Osborn, DPJ; Lewis, G; Dalman, C; Lundin, A; (2019) Visual Acuity in Late Adolescence and Future Psychosis Risk in a Cohort of 1 Million Men. Schizophrenia Bulletin , 45 (3) pp. 571-578. 10.1093/schbul/sby084 <https://doi.org/10.1093/schbul%2Fsby084>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10050950/8/Hayes%20VoR%20sby084.pdf