eprintid: 10050950
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/10/05/09/50
datestamp: 2018-06-25 10:11:54
lastmod: 2021-09-28 22:18:59
status_changed: 2019-06-24 14:05:46
type: article
metadata_visibility: show
creators_name: Hayes, JF
creators_name: Picot, S
creators_name: Osborn, DPJ
creators_name: Lewis, G
creators_name: Dalman, C
creators_name: Lundin, A
title: Visual Acuity in Late Adolescence and Future Psychosis Risk in a Cohort of 1 Million Men
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
keywords: eyesight, vision, schizophrenia, sibling-design
note: Copyright © The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Background: 
We aimed to determine whether late adolescent visual impairment is associated with later psychosis. //

Methods: 
We conducted a longitudinal cohort study of Swedish male military conscripts aged 18 or 19 years from January 1, 1974, through December 31, 1997 (N = 1140710). At conscription, uncorrected and optometry-lens-corrected distance visual acuity was measured. Participants were then followed up to see if they received an inpatient diagnosis of non-affective psychotic disorder, including schizophrenia (N = 10769). Multivariable Cox modeling was used to estimate differences between groups. //

Results: 
After adjustment for confounders, those with severe impairment before optical correction in their best eye (decimal fraction <0.3) had an increased psychosis rate compared to those with normal uncorrected vision (decimal fraction 1.0) (hazard ratio [HR] 1.26, 95% CI 1.16–1.37). Larger interocular visual acuity difference was associated with an increased psychosis rate (adjusted HR 1.49, 95% CI 1.37–1.63 in those with differences >0.5 compared to those with no between eye acuity difference). Individuals with impaired vision that could not be corrected to normal with lenses had highest rates of psychosis (best eye adjusted HR 1.56; 95% CI 1.33–1.82), those with imperfect, but correctable vision also had elevated rates (best eye adjusted HR 1.21; 95% CI 1.15–1.28). Individuals with visual impairment had higher rates of psychosis than their full siblings with normal vision (adjusted HR 1.20, 95% CI 1.07–1.35). //

Conclusions: 
Impaired visual acuity is associated with non-affective psychosis. Visual impairment as a phenotype in psychosis requires further consideration.
date: 2019-05
date_type: published
official_url: https://doi.org/10.1093/schbul/sby084
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1562336
doi: 10.1093/schbul/sby084
pii: 5036511
lyricists_name: Hayes, Joseph
lyricists_name: Lewis, Glyn
lyricists_name: Osborn, David
lyricists_id: JFHAY18
lyricists_id: GHLEW69
lyricists_id: DPJOS02
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Schizophrenia Bulletin
volume: 45
number: 3
pagerange: 571-578
event_location: United States
issn: 1745-1701
citation:        Hayes, JF;    Picot, S;    Osborn, DPJ;    Lewis, G;    Dalman, C;    Lundin, A;      (2019)    Visual Acuity in Late Adolescence and Future Psychosis Risk in a Cohort of 1 Million Men.                   Schizophrenia Bulletin , 45  (3)   pp. 571-578.    10.1093/schbul/sby084 <https://doi.org/10.1093/schbul%2Fsby084>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10050950/8/Hayes%20VoR%20sby084.pdf