eprintid: 10050943
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/05/09/43
datestamp: 2018-06-25 09:56:20
lastmod: 2020-02-12 21:48:48
status_changed: 2018-06-25 09:56:20
type: article
metadata_visibility: show
creators_name: Howe, LJ
creators_name: Erzurumluoglu, AM
creators_name: Davey Smith, G
creators_name: Rodriguez, S
creators_name: Stergiakouli, E
title: Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C09
divisions: D14
note: Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
abstract: Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.
date: 2017-09
date_type: published
official_url: https://doi.org/10.1038/s41598-017-10871-4
oa_status: green
full_text_type: pub
pmcid: PMC5599552
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1556029
doi: 10.1038/s41598-017-10871-4
pii: 10.1038/s41598-017-10871-4
lyricists_name: Howe, Laurence
lyricists_id: LJMSH63
actors_name: Cuccu, Clara
actors_id: CCCUC40
actors_role: owner
full_text_status: public
publication: Sci Rep
volume: 7
article_number: 11655
event_location: England
issn: 2045-2322
citation:        Howe, LJ;    Erzurumluoglu, AM;    Davey Smith, G;    Rodriguez, S;    Stergiakouli, E;      (2017)    Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits.                   Sci Rep , 7     , Article 11655.  10.1038/s41598-017-10871-4 <https://doi.org/10.1038/s41598-017-10871-4>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10050943/1/Howe_Y%20Chromosome.pdf
document_url: https://discovery.ucl.ac.uk/id/eprint/10050943/8/41598_2017_10871_MOESM1_ESM.pdf