<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10050665> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/title> "AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/abstract> "The discovery of mutations within genes associated with autosomal recessive Parkinson's disease allowed for the identification of PINK1/Parkin regulated mitophagy as an important pathway for the removal of damaged mitochondria. While recent studies suggest that AKT-dependent signalling regulates Parkin recruitment to depolarised mitochondria, little is known as to whether this can also regulate PINK1 mitochondrial accumulation and downstream mitophagy. Here, we demonstrate that inhibition of AKT signalling decreases endogenous PINK1 accumulation in response to mitochondria depolarisation, subsequent Parkin recruitment, phosphorylation of ubiquitin, and ultimately mitophagy. Conversely, we show that upon stimulation of AKT signalling via insulin, the mitophagy pathway is increased in SHSY5Y cells. These data suggest that AKT signalling is an upstream regulator of PINK1 accumulation on damaged mitochondria. Importantly, we show that the AKT pathway also regulates endogenous PINK1-dependent mitophagy in human iPSC-derived neurons."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/date> "2018-06-11" .
<https://discovery.ucl.ac.uk/id/document/684730> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/volume> "8" .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/issue> "1" .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Science Reports"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://purl.org/ontology/bibo/issn> "20452322" .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8a3ccb42fa6a65cd004cf9e7e62183fb> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-8a3ccb42fa6a65cd004cf9e7e62183fb> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e61a8184b95dbd5cfc7115e6c80fcdba> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-e61a8184b95dbd5cfc7115e6c80fcdba> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4eebbf3599e56f36a931a7397c3d3f3d> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-4eebbf3599e56f36a931a7397c3d3f3d> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ec837252326e2e5246212a22b01230e8> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-ec837252326e2e5246212a22b01230e8> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bce3c14627f548771c8f23f4962906e3> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-bce3c14627f548771c8f23f4962906e3> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d8a585116cc887699b4ea6411d9e40a4> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-d8a585116cc887699b4ea6411d9e40a4> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-918139389b54ef1d696987388209118b> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-918139389b54ef1d696987388209118b> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3d214409badf5422be0e655e423dbf34> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-3d214409badf5422be0e655e423dbf34> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9a01d1aa28f8664a6f5c9e757edf0bf1> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-9a01d1aa28f8664a6f5c9e757edf0bf1> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e28761626a478675b2f486c85e2fa38d> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-e28761626a478675b2f486c85e2fa38d> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-43e78633adb86371d91142d60303ba71> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-43e78633adb86371d91142d60303ba71> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a0b765f75012aa6074b4ab07b459d23e> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-a0b765f75012aa6074b4ab07b459d23e> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-903431325304ef05d296d21b3b1b3602> .
<https://discovery.ucl.ac.uk/id/eprint/10050665> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050665#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050665#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-903431325304ef05d296d21b3b1b3602> .
<https://discovery.ucl.ac.uk/id/person/ext-918139389b54ef1d696987388209118b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-918139389b54ef1d696987388209118b> <http://xmlns.com/foaf/0.1/givenName> "GA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-918139389b54ef1d696987388209118b> <http://xmlns.com/foaf/0.1/familyName> "O'Sullivan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-918139389b54ef1d696987388209118b> <http://xmlns.com/foaf/0.1/name> "GA O'Sullivan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a3ccb42fa6a65cd004cf9e7e62183fb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8a3ccb42fa6a65cd004cf9e7e62183fb> <http://xmlns.com/foaf/0.1/givenName> "MPM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a3ccb42fa6a65cd004cf9e7e62183fb> <http://xmlns.com/foaf/0.1/familyName> "Soutar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8a3ccb42fa6a65cd004cf9e7e62183fb> <http://xmlns.com/foaf/0.1/name> "MPM Soutar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d8a585116cc887699b4ea6411d9e40a4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d8a585116cc887699b4ea6411d9e40a4> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d8a585116cc887699b4ea6411d9e40a4> <http://xmlns.com/foaf/0.1/familyName> "Harley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d8a585116cc887699b4ea6411d9e40a4> <http://xmlns.com/foaf/0.1/name> "J Harley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9a01d1aa28f8664a6f5c9e757edf0bf1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9a01d1aa28f8664a6f5c9e757edf0bf1> <http://xmlns.com/foaf/0.1/givenName> "DC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9a01d1aa28f8664a6f5c9e757edf0bf1> <http://xmlns.com/foaf/0.1/familyName> "Hancock"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9a01d1aa28f8664a6f5c9e757edf0bf1> <http://xmlns.com/foaf/0.1/name> "DC Hancock"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-903431325304ef05d296d21b3b1b3602> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-903431325304ef05d296d21b3b1b3602> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-903431325304ef05d296d21b3b1b3602> <http://xmlns.com/foaf/0.1/familyName> "Plun-Favreau"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-903431325304ef05d296d21b3b1b3602> <http://xmlns.com/foaf/0.1/name> "H Plun-Favreau"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e28761626a478675b2f486c85e2fa38d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e28761626a478675b2f486c85e2fa38d> <http://xmlns.com/foaf/0.1/givenName> "MR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e28761626a478675b2f486c85e2fa38d> <http://xmlns.com/foaf/0.1/familyName> "Cookson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e28761626a478675b2f486c85e2fa38d> <http://xmlns.com/foaf/0.1/name> "MR Cookson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4eebbf3599e56f36a931a7397c3d3f3d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4eebbf3599e56f36a931a7397c3d3f3d> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4eebbf3599e56f36a931a7397c3d3f3d> <http://xmlns.com/foaf/0.1/familyName> "Miyakawa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4eebbf3599e56f36a931a7397c3d3f3d> <http://xmlns.com/foaf/0.1/name> "S Miyakawa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a0b765f75012aa6074b4ab07b459d23e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a0b765f75012aa6074b4ab07b459d23e> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a0b765f75012aa6074b4ab07b459d23e> <http://xmlns.com/foaf/0.1/familyName> "Carlton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a0b765f75012aa6074b4ab07b459d23e> <http://xmlns.com/foaf/0.1/name> "M Carlton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43e78633adb86371d91142d60303ba71> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-43e78633adb86371d91142d60303ba71> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43e78633adb86371d91142d60303ba71> <http://xmlns.com/foaf/0.1/familyName> "Downward"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43e78633adb86371d91142d60303ba71> <http://xmlns.com/foaf/0.1/name> "J Downward"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3d214409badf5422be0e655e423dbf34> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3d214409badf5422be0e655e423dbf34> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3d214409badf5422be0e655e423dbf34> <http://xmlns.com/foaf/0.1/familyName> "Wray"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3d214409badf5422be0e655e423dbf34> <http://xmlns.com/foaf/0.1/name> "S Wray"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bce3c14627f548771c8f23f4962906e3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-bce3c14627f548771c8f23f4962906e3> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bce3c14627f548771c8f23f4962906e3> <http://xmlns.com/foaf/0.1/familyName> "Melandri"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bce3c14627f548771c8f23f4962906e3> <http://xmlns.com/foaf/0.1/name> "D Melandri"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ec837252326e2e5246212a22b01230e8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ec837252326e2e5246212a22b01230e8> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ec837252326e2e5246212a22b01230e8> <http://xmlns.com/foaf/0.1/familyName> "Annuario"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ec837252326e2e5246212a22b01230e8> <http://xmlns.com/foaf/0.1/name> "E Annuario"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e61a8184b95dbd5cfc7115e6c80fcdba> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e61a8184b95dbd5cfc7115e6c80fcdba> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
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