<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10050137> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/title> "EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/abstract> "Glioblastomas (GBM) are aggressive and therapy-resistant brain tumours, which\r\ncontain a subpopulation of tumour-propagating glioblastoma stem-like cells (GSC) thought to drive\r\nprogression and recurrence. Diffuse invasion of the brain parenchyma, including along preexisting\r\nblood vessels, is a leading cause of therapeutic resistance, but the mechanisms remain unclear.\r\nHere, we show that ephrin-B2 mediates GSC perivascular invasion. Intravital imaging, coupled with\r\nmechanistic studies in murine GBM models and patient-derived GSC, revealed that endothelial\r\nephrin-B2 compartmentalises non-tumourigenic cells. In contrast, upregulation of the same ephrinB2\r\nligand in GSC enabled perivascular migration through homotypic forward signalling.\r\nSurprisingly, ephrin-B2 reverse signalling also promoted tumourigenesis cell-autonomously, by\r\nmediating anchorage-independent cytokinesis via RhoA. In human GSC-derived orthotopic\r\nxenografts, EFNB2 knock-down blocked tumour initiation and treatment of established tumours\r\nwith ephrin-B2-blocking antibodies suppressed progression. Thus, our results indicate that\r\ntargeting ephrin-B2 may be an effective strategy for the simultaneous inhibition of invasion and\r\nproliferation in GBM."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/date> "2016-06-28" .
<https://discovery.ucl.ac.uk/id/document/679963> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/volume> "5" .
<https://discovery.ucl.ac.uk/id/org/ext-a0b53ade2e9a8ec8ab6a6125642719aa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-a0b53ade2e9a8ec8ab6a6125642719aa> <http://xmlns.com/foaf/0.1/name> "ELIFE SCIENCES PUBLICATIONS LTD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-a0b53ade2e9a8ec8ab6a6125642719aa> .
<https://discovery.ucl.ac.uk/id/publication/ext-2050084X> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-2050084X> <http://xmlns.com/foaf/0.1/name> "eLife"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-2050084X> .
<https://discovery.ucl.ac.uk/id/publication/ext-2050084X> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:2050084X> .
<https://discovery.ucl.ac.uk/id/publication/ext-2050084X> <http://purl.org/ontology/bibo/issn> "2050084X" .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-be19b5cff8ae88e25622b9c05222c846> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-be19b5cff8ae88e25622b9c05222c846> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b38e85dd35ec357d952ad1b9f1c7d92b> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-b38e85dd35ec357d952ad1b9f1c7d92b> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-14eb57dd8e7e0b91bc66163de4542ab9> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-14eb57dd8e7e0b91bc66163de4542ab9> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c2ccb5394cee5090f2fdb9d1431cc899> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-c2ccb5394cee5090f2fdb9d1431cc899> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e543b4fe6d62011bd34fc1f52a666f9b> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-e543b4fe6d62011bd34fc1f52a666f9b> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1c0508da902d74f956f7def8e142beeb> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-1c0508da902d74f956f7def8e142beeb> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-970fb8b4af3134ee9d782d56fa5c310f> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-970fb8b4af3134ee9d782d56fa5c310f> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0fdbf36ae46983eac1e8fad68887cea3> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-0fdbf36ae46983eac1e8fad68887cea3> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4ab418674b9dff458bb3eb43f4bc270e> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-4ab418674b9dff458bb3eb43f4bc270e> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cad020114be67a860283494cc1878e41> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-cad020114be67a860283494cc1878e41> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4a8f24438f46d0e28c6d7398e80daa20> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-4a8f24438f46d0e28c6d7398e80daa20> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-745187a5d265b92c13ba2ebe83a1a92e> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-745187a5d265b92c13ba2ebe83a1a92e> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-769dc98f64978fc1a07e3d1f79c37c75> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-769dc98f64978fc1a07e3d1f79c37c75> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-af2e55aeb86d9fb39184db864a82c228> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-af2e55aeb86d9fb39184db864a82c228> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-858db29164f4e5d17df04cc0e71cf796> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-858db29164f4e5d17df04cc0e71cf796> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d6e8566505752137e1768890418510a5> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-d6e8566505752137e1768890418510a5> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bf909191a6c59271a56c35363161c873> .
<https://discovery.ucl.ac.uk/id/eprint/10050137> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10050137#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10050137#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-bf909191a6c59271a56c35363161c873> .
<https://discovery.ucl.ac.uk/id/person/ext-be19b5cff8ae88e25622b9c05222c846> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-be19b5cff8ae88e25622b9c05222c846> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be19b5cff8ae88e25622b9c05222c846> <http://xmlns.com/foaf/0.1/familyName> "Krusche"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be19b5cff8ae88e25622b9c05222c846> <http://xmlns.com/foaf/0.1/name> "B Krusche"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0508da902d74f956f7def8e142beeb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0508da902d74f956f7def8e142beeb> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0508da902d74f956f7def8e142beeb> <http://xmlns.com/foaf/0.1/familyName> "Lieven"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c0508da902d74f956f7def8e142beeb> <http://xmlns.com/foaf/0.1/name> "H Lieven"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-14eb57dd8e7e0b91bc66163de4542ab9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-14eb57dd8e7e0b91bc66163de4542ab9> <http://xmlns.com/foaf/0.1/givenName> "MP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-14eb57dd8e7e0b91bc66163de4542ab9> <http://xmlns.com/foaf/0.1/familyName> "clements"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-14eb57dd8e7e0b91bc66163de4542ab9> <http://xmlns.com/foaf/0.1/name> "MP clements"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ccb5394cee5090f2fdb9d1431cc899> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ccb5394cee5090f2fdb9d1431cc899> <http://xmlns.com/foaf/0.1/givenName> "ER"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ccb5394cee5090f2fdb9d1431cc899> <http://xmlns.com/foaf/0.1/familyName> "Johnstone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c2ccb5394cee5090f2fdb9d1431cc899> <http://xmlns.com/foaf/0.1/name> "ER Johnstone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4ab418674b9dff458bb3eb43f4bc270e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4ab418674b9dff458bb3eb43f4bc270e> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4ab418674b9dff458bb3eb43f4bc270e> <http://xmlns.com/foaf/0.1/familyName> "Khadayate"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4ab418674b9dff458bb3eb43f4bc270e> <http://xmlns.com/foaf/0.1/name> "S Khadayate"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8f24438f46d0e28c6d7398e80daa20> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8f24438f46d0e28c6d7398e80daa20> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8f24438f46d0e28c6d7398e80daa20> <http://xmlns.com/foaf/0.1/familyName> "Davies"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8f24438f46d0e28c6d7398e80daa20> <http://xmlns.com/foaf/0.1/name> "T Davies"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e543b4fe6d62011bd34fc1f52a666f9b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e543b4fe6d62011bd34fc1f52a666f9b> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e543b4fe6d62011bd34fc1f52a666f9b> <http://xmlns.com/foaf/0.1/familyName> "Goetsch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e543b4fe6d62011bd34fc1f52a666f9b> <http://xmlns.com/foaf/0.1/name> "K Goetsch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-769dc98f64978fc1a07e3d1f79c37c75> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-769dc98f64978fc1a07e3d1f79c37c75> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-769dc98f64978fc1a07e3d1f79c37c75> <http://xmlns.com/foaf/0.1/familyName> "De Paola"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-769dc98f64978fc1a07e3d1f79c37c75> <http://xmlns.com/foaf/0.1/name> "V De Paola"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b38e85dd35ec357d952ad1b9f1c7d92b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b38e85dd35ec357d952ad1b9f1c7d92b> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b38e85dd35ec357d952ad1b9f1c7d92b> <http://xmlns.com/foaf/0.1/familyName> "Ottone"^^<http://www.w3.org/2001/XMLSchema#string> .
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