eprintid: 10049810 rev_number: 33 eprint_status: archive userid: 608 dir: disk0/10/04/98/10 datestamp: 2019-03-12 14:24:24 lastmod: 2021-09-26 22:37:57 status_changed: 2019-03-12 14:24:24 type: book_section metadata_visibility: show creators_name: Rodrigues, FB creators_name: Byrne, LM creators_name: Wild, EJ title: Biofluid Biomarkers in Huntington's Disease ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: Biomarkers, Blood, Cerebrospinal fluid, Huntington’s disease, Review, Urine, Biomarkers, Body Fluids, Brain, Drug Development, Humans, Huntingtin Protein, Huntington Disease, Inflammation Mediators, Neurons, Neurotransmitter Agents, Oxidative Stress, Proteomics, Transglutaminases note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Huntington's disease (HD) is a chronic progressive neurodegenerative condition where new markers of disease progression are needed. So far no disease-modifying interventions have been found, and few interventions have been proven to alleviate symptoms. This may be partially explained by the lack of reliable indicators of disease severity, progression, and phenotype.Biofluid biomarkers may bring advantages in addition to clinical measures, such as reliability, reproducibility, price, accuracy, and direct quantification of pathobiological processes at the molecular level; and in addition to empowering clinical trials, they have the potential to generate useful hypotheses for new drug development.In this chapter we review biofluid biomarker reports in HD, emphasizing those we feel are likely to be closest to clinical applicability. date: 2018 date_type: published publisher: Humana Press official_url: https://doi.org/10.1007/978-1-4939-7825-0_17 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1560269 doi: 10.1007/978-1-4939-7825-0_17 isbn_13: 978-1-4939-7824-3 lyricists_name: Brogueira Rodrigues, Filipe lyricists_name: Byrne, Lauren Mary lyricists_name: Wild, Edward lyricists_id: FBROG17 lyricists_id: LMBYR59 lyricists_id: EJWIL36 actors_name: Novi, Maya actors_id: MNOVI52 actors_role: owner full_text_status: public series: Methods in Molecular Biology book series volume: 1780 place_of_pub: New York, NY, USA pagerange: 329-396 book_title: Huntington’s Disease editors_name: Precious, SV editors_name: Rosser, AE editors_name: Dunnett, SB citation: Rodrigues, FB; Byrne, LM; Wild, EJ; (2018) Biofluid Biomarkers in Huntington's Disease. In: Precious, SV and Rosser, AE and Dunnett, SB, (eds.) Huntington’s Disease. (pp. 329-396). Humana Press: New York, NY, USA. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10049810/9/Rodrigues_07%20Wild%20Fluid%20Biomarkers%20sbd%20svr%20edits%20v11.pdf