TY  - JOUR
EP  - 86
VL  - 67
AV  - public
SP  - 56
Y1  - 2018/11//
TI  - A new perspective on lipid research in age-related macular degeneration
N1  - © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode).
SN  - 1350-9462
UR  - https://doi.org/10.1016/j.preteyeres.2018.04.006
ID  - discovery10049644
N2  - There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.
KW  - Age-related macular degeneration (AMD)
KW  -  High-density lipoprotein cholesterol (HDL-C)
KW  -  Dietary lipids
KW  -  Circulating lipoproteins
KW  -  Retinal lipids
KW  -  Genetics
A1  - van Leeuwen, EM
A1  - Emri, E
A1  - Merle, BMJ
A1  - Colijn, JM
A1  - Kersten, E
A1  - Cougnard-Gregoire, A
A1  - Dammeier, S
A1  - Meester-Smoor, M
A1  - Pool, FM
A1  - de Jong, EK
A1  - Delcourt, C
A1  - Rodrigez-Bocanegra, E
A1  - Biarnés, M
A1  - Luthert, PJ
A1  - Ueffing, M
A1  - Klaver, CCW
A1  - Nogoceke, E
A1  - den Hollander, AI
A1  - Lengyel, I
JF  - Progress in Retinal and Eye Research
ER  -