<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10048831> . <https://discovery.ucl.ac.uk/id/eprint/10048831> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10048831> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10048831> <http://purl.org/dc/terms/title> "Ðльфа-Ñинуклеин и диÑÑ„ÑƒÐ½ÐºÑ†Ð¸Ñ Ð¼Ð¸Ñ‚Ð¾Ñ…Ð¾Ð½Ð´Ñ€Ð¸Ð¹ при болезни паркинÑона"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10048831> <http://purl.org/ontology/bibo/abstract> "Болезнь ПаркинÑона (БП) - одно из Ñамых раÑпроÑтраненных нейродегенеративных заболеваний. Развитие патологии ÑвÑзано Ñ Ð³Ð¸Ð±ÐµÐ»ÑŒÑŽ дофаминергичеÑких нейронов, главным образом, в черной ÑубÑтанции головного мозга. ÐедоÑтаточноÑÑ‚ÑŒ дофамина вызывает целый набор Ñ‚Ñжелых Ñимптомов, Ñреди которых брадикинезиÑ, поÑÑ‚ÑƒÑ€Ð°Ð»ÑŒÐ½Ð°Ñ Ð½ÐµÑƒÑтойчивоÑÑ‚ÑŒ, ригидноÑÑ‚ÑŒ мышц и тремор. ГенетичеÑкие иÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¸, что ведущую роль в патогенезе БП играет белок альфа-Ñинуклеин (?-Син). Большое количеÑтво данных ÑвидетельÑтвует о различных механизмах токÑичеÑкого дейÑÑ‚Ð²Ð¸Ñ ?-Син. Кроме того, Ñреди ключевых факторов, ÑпоÑобÑтвующих развитию нейродегенерации при БП, выделÑÑŽÑ‚ ÑущеÑтвенные Ð½Ð°Ñ€ÑƒÑˆÐµÐ½Ð¸Ñ Ñ„ÑƒÐ½ÐºÑ†Ð¸Ð¹ митохондрий и/или мутации. Ð’ чиÑло мутируемых генов при наÑледÑтвенной и ÑпорадичеÑкой формах БП входÑÑ‚ гены, кодирующие PINK1 и Parkin, оÑновные компоненты ÑиÑтемы â€œÐºÐ¾Ð½Ñ‚Ñ€Ð¾Ð»Ñ ÐºÐ°Ñ‡ÐµÑтва†митохондрий. Самые ранние биохимичеÑкие признаки Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ Ð¿Ñ€Ð¾ÑвлÑÑŽÑ‚ÑÑ Ð² нарушениÑÑ… взаимодейÑÑ‚Ð²Ð¸Ñ Ð¼Ð¸Ñ‚Ð¾Ñ…Ð¾Ð½Ð´Ñ€Ð¸Ð¹ и ÑндоплазматичеÑкого ретикулума, митохондриальной динамики, гомеоÑтаза ÐºÐ°Ð»ÑŒÑ†Ð¸Ñ Ð¸ повышении ÑƒÑ€Ð¾Ð²Ð½Ñ Ð¼Ð¸Ñ‚Ð¾Ñ…Ð¾Ð½Ð´Ñ€Ð¸Ð°Ð»ÑŒÐ½Ñ‹Ñ… активных форм киÑлорода. 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