TY  - JOUR
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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TI  - Disrupted Module Efficiency of Structural and Functional Brain Connectomes in Clinically Isolated Syndrome and Multiple Sclerosis
EP  - 11
AV  - public
Y1  - 2018/04/10/
VL  - 12
JF  - Frontiers in Human Neuroscience
KW  - Science & Technology
KW  -  Social Sciences
KW  -  Life Sciences & Biomedicine
KW  -  Neurosciences
KW  -  Psychology
KW  -  Neurosciences & Neurology
KW  -  multiple sclerosis
KW  -  clinically isolated syndrome
KW  -  diffusion MRI
KW  -  functional MRI
KW  -  graph theory
KW  -  brain network
KW  -  RESTING-STATE
KW  -  COGNITIVE IMPAIRMENT
KW  -  DEFAULT-MODE
KW  -  LESION LOAD
KW  -  NETWORKS
KW  -  CONNECTIVITY
KW  -  DISABILITY
KW  -  PATHOGENESIS
KW  -  ORGANIZATION
KW  -  TRACTOGRAPHY
A1  - Liu, Y
A1  - Duan, Y
A1  - Dong, H
A1  - Barkhof, F
A1  - Li, K
A1  - Shu, N
ID  - discovery10048726
N2  - Recent studies have demonstrated disrupted topological organization of brain
connectome in multiple sclerosis (MS). However, whether the communication efficiency
between different functional systems is affected in the early stage of MS remained largely
unknown. In this study, we constructed the structural connectivity (SC) and functional
connectivity (FC) networks in 41 patients with clinically isolated syndrome (CIS), 32 MS
patients and 35 healthy controls (HC) based on diffusion and resting-state functional
MRI. To quantify the communication efficiency within and between different functional
systems, we proposed two measures called intra- and inter-module efficiency. Based
on the module parcellation of functional backbone network, the intra- and inter-module
efficiency of SC and FC networks was calculated for each participant. For the SC
network, CIS showed decreased inter-module efficiency between the sensory-motor
network (SMN), the visual network (VN), the default-mode network (DMN) and the
fronto-parietal network (FPN) compared with HC, while MS showed more widespread
decreased module efficiency both within and between modules relative to HC and CIS.
For the FC network, no differences were found between CIS and HC, and a decreased
inter-module efficiency between SMN and FPN and between VN and FPN was identified
in MS, compared with HC and CIS. Moreover, both intra- and inter-module efficiency of
SC network were correlated with the disability and cognitive scores in MS. Therefore, our
results demonstrated early SC changes between modules in CIS, and more widespread
SC alterations and inter-module FC changes were observed in MS, which were further
associated with cognitive impairment and physical disability.
SN  - 1662-5161
PB  - FRONTIERS MEDIA SA
UR  - https://doi.org/10.3389/fnhum.2018.00138
ER  -