eprintid: 10048537 rev_number: 21 eprint_status: archive userid: 608 dir: disk0/10/04/85/37 datestamp: 2018-05-17 14:35:00 lastmod: 2021-09-24 22:07:16 status_changed: 2018-05-17 14:35:00 type: article metadata_visibility: show creators_name: Clark, JE creators_name: Watson, S creators_name: Friston, KJ title: What is mood? A computational perspective ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F83 note: © Cambridge University Press 2018 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: The neurobiological understanding of mood, and by extension mood disorders, remains elusive despite decades of research implicating several neuromodulator systems. This review considers a new approach based on existing theories of functional brain organisation. The free energy principle (a.k.a. active inference), and its instantiation in the Bayesian brain, offers a complete and simple formulation of mood. It has been proposed that emotions reflect the precision of – or certainty about – the predicted sensorimotor/interoceptive consequences of action. By extending this reasoning, in a hierarchical setting, we suggest mood states act as (hyper) priors over uncertainty (i.e. emotions). Here, we consider the same computational pathology in the proprioceptive and interoceptive (behavioural and autonomic) domain in order to furnish an explanation for mood disorders. This formulation reconciles several strands of research at multiple levels of enquiry. date: 2018-10 date_type: published official_url: http://dx.doi.org/10.1017/S0033291718000430 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Article in Press verified: verified_manual elements_id: 1541952 doi: 10.1017/S0033291718000430 lyricists_name: Friston, Karl lyricists_id: KJFRI52 actors_name: Barczynska, Patrycja actors_id: PBARC91 actors_role: owner full_text_status: public publication: Psychological Medicine volume: 48 number: 14 pagerange: 2277-2284 issn: 1469-8978 citation: Clark, JE; Watson, S; Friston, KJ; (2018) What is mood? A computational perspective. Psychological Medicine , 48 (14) pp. 2277-2284. 10.1017/S0033291718000430 <https://doi.org/10.1017/S0033291718000430>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10048537/1/what_is_mood_a_computational_perspective.pdf